Machine learning algorithms revealed distorted retinal vascular branching in individuals with bipolar disorder

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dc.authoridAtagun, Murat Ilhan/0000-0002-8514-0576
dc.authoridUGURLU, NAGIHAN/0000-0002-1072-6126
dc.authoridSONUGUR, GURAY/0000-0003-1521-7010
dc.contributor.authorAtagun, Murat Ilhan
dc.contributor.authorSonugur, Guray
dc.contributor.authorYusifova, Aygun
dc.contributor.authorCelik, Ibrahim
dc.contributor.authorUgurlu, Nagihan
dc.date.accessioned2025-01-27T20:31:43Z
dc.date.available2025-01-27T20:31:43Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Converging evidence designate vascular vulnerability in bipolar disorder. The predisposition pro-gresses into distortion in time, thus detection of the vascular susceptibility may help reducing morbidity and mortality. It was aimed to assess retinal fundus vasculature in cardiovascular risk-free patients with bipolar disorder. Methods: Total of 68 individuals (38 patients with bipolar disorder, 30 healthy controls) were enrolled. In order to avoid from degenerative processes, participants were between 18 and 45 years of age, vascular risk factors were eliminated. Microscopic retinal fundus images were processed with machine learning algorithms (multi -layer perceptron and support vector machine) and artificial neural network approaches. Results: In comparison to the healthy control group, the bipolar disorder group had lower number of breaking points (P < 0.001), lower number of curved vessel segments (P < 0.001). Total length of smooth vessels was longer (P = 0.040), and total length of curved vessel segments was significantly shorter (P < 0.001) than the control group. Vascular endothelial growth factor levels and gender were the confounders. There were significant correlations between vascular measures and serum lipid levels.Limitations: Sample size was small and patients were on various medications. Conclusions: These results indicate distortion in retinal vascular branching in bipolar disorder. Disrupted branching may reflect disturbed prosperity of retinal vascular plexus in patients with bipolar disorder. Alter-ations in the retinal vessels might be indicators of disruption in cerebral vascular system efficiency and thus neurovascular unit dysfunction in bipolar disorder.
dc.description.sponsorshipAnkara Yildirim Beyazit University, Scientific Research ProjectsCommittee grant [4730]
dc.description.sponsorshipFunding The study was supported by Ankara Yildirim Beyazit University, Scientific Research ProjectsCommittee grant (to Dr. Atag?n, project no: 4730) .
dc.identifier.doi10.1016/j.jad.2022.07.060
dc.identifier.endpage41
dc.identifier.issn0165-0327
dc.identifier.issn1573-2517
dc.identifier.pmid35905794
dc.identifier.scopus2-s2.0-85135097744
dc.identifier.scopusqualityQ1
dc.identifier.startpage35
dc.identifier.urihttps://doi.org/10.1016/j.jad.2022.07.060
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23251
dc.identifier.volume315
dc.identifier.wosWOS:000848145600006
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Affective Disorders
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBipolar disorder
dc.subjectRetina
dc.subjectVascular plexus
dc.titleMachine learning algorithms revealed distorted retinal vascular branching in individuals with bipolar disorder
dc.typeArticle

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