The Neuroprotective Effect of Coumaric Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats

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dc.authoridKaravelioglu, Ergun/0000-0002-6611-1032
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorGuven, Mustafa
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorYuksel, Yasemin
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.contributor.authorGolge, Umut Hatay
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe main causes of spinal cord ischemia are a variety of vascular pathologies causing acute arterial occlusions. We investigated neuroprotective effects of coumaric acid on spinal cord ischemia injury in rats. Rats were divided randomly into four groups of eight animals as follows: control, ischemia, ischemia + coumaric acid, and ischemia + methylprednisolone. In the control group, only a laparotomy was performed. In all other groups, the spinal cord ischemia was performed by the infrarenal aorta cross-clamping model. Levels of malondialdehyde and nuclear respiratory factor 1 were analyzed, as were the activity of superoxide dismutase. Histopathological and immunohistochemical evaluations were performed. Neurological evaluation was performed with the Tarlov scoring system. The ischemia + coumaric acid group was compared with the ischemia group, and a significant decrease in malondialdehyde and levels was observed. Nuclear respiratory factor 1 level and superoxide dismutase activity of the ischemia + coumaric acid group were significantly higher than in the ischemia group. In histopathological samples, the ischemia + coumaric acid group is compared with the ischemia group, and there was a significant increase in numbers of normal neurons. In immunohistochemical staining, hypoxia-inducible factor-1 alpha and NF-kappa B immunopositive neurons were significantly decreased in the ischemia + coumaric acid group compared with that in the ischemia group. The neurological deficit scores of the ischemia + coumaric acid group were significantly higher than the ischemia group at 24 h. Our results revealed for the first time that coumaric acid exhibits meaningful neuroprotective activity following ischemia-reperfusion injury of the spinal cord.
dc.identifier.doi10.1007/s10753-015-0179-0
dc.identifier.endpage1995
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue5
dc.identifier.pmid25943038
dc.identifier.scopus2-s2.0-84941181223
dc.identifier.scopusqualityQ1
dc.identifier.startpage1986
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0179-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23989
dc.identifier.volume38
dc.identifier.wosWOS:000360847200028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcoumaric acids
dc.subjectspinal cord ischemia
dc.subjecthypoxia-inducible factor 1
dc.subjectNF-kappa B
dc.titleThe Neuroprotective Effect of Coumaric Acid on Spinal Cord Ischemia/Reperfusion Injury in Rats
dc.typeArticle

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