Mcl-1 is a potential therapeutic target in multiple types of cancer

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dc.contributor.authorAkgul, C.
dc.date.accessioned2025-01-27T20:14:59Z
dc.date.available2025-01-27T20:14:59Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractResistance to apoptosis is a common challenge in human malignancies contributing to both progress of cancer and resistance to conventional therapeutics. Abnormalities in a variety of cell intrinsic and extrinsic molecular mechanisms cooperatively promote tumor formation. Therapeutic approaches that specifically target components of these molecular mechanisms are getting widespread attention. Mcl-1 is a highly expressed pro-survival protein in human malignancies and its cellular expression is tightly regulated via multiple mechanisms. Mcl-1 differs from other members of the Bcl-2 family in having a very short half-life. So inhibition of its expression and/or neutralization of its anti-apoptotic function will rapidly make Mcl-1-dependent cells more susceptible to apoptosis and provide an opportunity to combat several types of cancers. This review summarizes the current knowledge on the regulation of Mcl-1 expression and discusses the alternative approaches targeting Mcl-1 in human cancer cells whose survivals mainly depend on Mcl-1.
dc.identifier.doi10.1007/s00018-008-8637-6
dc.identifier.endpage1336
dc.identifier.issn1420-682X
dc.identifier.issue8
dc.identifier.pmid19099185
dc.identifier.scopus2-s2.0-67349136004
dc.identifier.scopusqualityQ1
dc.identifier.startpage1326
dc.identifier.urihttps://doi.org/10.1007/s00018-008-8637-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21251
dc.identifier.volume66
dc.identifier.wosWOS:000265248200002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBirkhauser Verlag Ag
dc.relation.ispartofCellular and Molecular Life Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectcancer
dc.subjectBcl-2 family
dc.subjectMcl-1
dc.subjecttherapeutic
dc.titleMcl-1 is a potential therapeutic target in multiple types of cancer
dc.typeReview Article

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