Evaluation of Mitochondrial Copy Number in Thyroid Disorders

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dc.authoridCaglar Cil, ozge/0000-0001-8737-2891
dc.contributor.authorCil, Ozge Caglar
dc.contributor.authorMetin, Ozge Karakas
dc.contributor.authorCayir, Akin
dc.date.accessioned2025-01-27T20:20:16Z
dc.date.available2025-01-27T20:20:16Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective. The purpose of this study was to determine whether the mitochondrial DNA (mitDNA) copy number in blood samples of patients with thyroiditis, benign nodules or malignant nodules is different from that in healthy individuals, and to examine whether mtDNAcn has the ability to distinguish between different thyroid diseases. Materials and Method. This study consists of principal groups as thyroid patients and control group. The thyroid patient group comprised 30 patients with malignant nodules, 33 with benign nodules and 31 with thyroiditis, whereas the control group was com-posed of 21 healthy individuals. Blood samples were collected from the patients before treatment. Results were evaluated between groups. Results. We could not find an adequate number of participants for inclusion to match the groups. Similarly, since there is a gender difference in terms of disease prevalence, it was not possible to pair the populations in terms of gender. Instead, the results were analyzed with an adjusted model, including man characteristics as cofounders. We found that the mtDNAcn of the thyroid patients was significantly lower than that measured for the control group ( p = 0.01). Furthermore the mtDNAcn of the benign group was significantly lower than that measured in the control group ( p = 0.0001). A similar significant difference was found between the thyroiditis group and the control group ( p = 0.005). Conclusion. It was observed that mtDNAcn in the malignant group was significantly higher than that measured in the benign group ( p = 0.004), which would indicate that it may be used as a diagnostic and therapeutic marker in thyroid diseases. (c) 2022 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.
dc.description.sponsorshipCanakkale Onsekiz Mart University - Scientific Research Coordination Unit [TSA-2017-1286]
dc.description.sponsorshipThis work was supported by Canakkale Onsekiz Mart University - Scientific Research Coordination Unit, Project number: TSA-2017-1286.
dc.identifier.doi10.1016/j.arcmed.2022.10.003
dc.identifier.endpage717
dc.identifier.issn0188-4409
dc.identifier.issn1873-5487
dc.identifier.issue7
dc.identifier.pmid36307229
dc.identifier.scopus2-s2.0-85140383041
dc.identifier.scopusqualityQ1
dc.identifier.startpage711
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2022.10.003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21646
dc.identifier.volume53
dc.identifier.wosWOS:000961065100008
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Inc
dc.relation.ispartofArchives of Medical Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectThyroid disease
dc.subjectmitDNA
dc.subjectThyroiditis
dc.subjectInflammation
dc.subjectMalign neoplasm
dc.subjectbenign neoplasm
dc.titleEvaluation of Mitochondrial Copy Number in Thyroid Disorders
dc.typeArticle

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