677C>T and 1298A>C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta

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dc.authoridASLAN, ADEM/0000-0001-9432-5399
dc.contributor.authorEser, Betul
dc.contributor.authorCosar, Murat
dc.contributor.authorEser, Olcay
dc.contributor.authorErdogan, Mujgan O.
dc.contributor.authorAslan, Adem
dc.contributor.authorYildiz, Handan
dc.contributor.authorBoyaci, Gazi
dc.date.accessioned2025-01-27T20:47:25Z
dc.date.available2025-01-27T20:47:25Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAIM: This study aimed to investigate the 677C>T and 1298A>C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. MATERIAL and METHODS: A case-control study was performed to detect 677C>T and 1298A>C MTHFR gene polymorphisms in 39 SBO patients and 34 healthy individuals. The folate, vitamin B12 and homocysteine concentrations in the serum of SBO and healthy individuals were evaluated and compared with MTHFR gene polymorphisms. RESULTS: 677 CC/CT/TT MTHFR genotype frequency differences between the SBO patients and controls were not significant (x(2)=3.325, P=0.068; x(2)=1.479, P=0.224; x(2)=0.275, P=0.600; respectively). 1298A>C MTHFR genotype frequency differences between the SBO patients and controls were significant (x(2)=8.477, P=0.004). The frequencies of the A and C alleles of the 1298A>C polymorphism did not differ in a statistically significant manner between the groups (x(2)=0.576, P=0.448). The biochemical parameters were not significantly different between SBO patients and healthy individuals (P>0.05). CONCLUSION: The 677C>T and 1298A>C polymorphisms of the MTHFR gene cannot be regarded as major risk factors for SBO in the Turkish patients 677TT homozygosity may affect the metabolism of homocysteine.
dc.identifier.endpage15
dc.identifier.issn1019-5149
dc.identifier.issue1
dc.identifier.pmid20066615
dc.identifier.scopus2-s2.0-77951651289
dc.identifier.scopusqualityQ3
dc.identifier.startpage9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24894
dc.identifier.volume20
dc.identifier.wosWOS:000274702500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subject1298A > C polymorphism
dc.subject677C > T polymorphism
dc.subjectFolate
dc.subjectHomocysteine
dc.subjectMTHFR Spina bifida occulta
dc.subjectVitamin B12
dc.title677C>T and 1298A>C Polymorphisms of Methylenetetrahydropholate Reductase Gene and Biochemical Parameters in Turkish Population with Spina Bifida Occulta
dc.title.alternativeSpina bifida okkultali hastalarda metilentetrahidrofolat redüktaz (MTHFR) geninin C677T ve A1298C polimorfizmlerinin analizi ve biyokimyasal parametrelerinin de?erlendirilmesi
dc.typeArticle

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