Biofilm inhibition and bacterial eradication by C-dots derived from polyethyleneimine-citric acid

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dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorAbraham, Wakeem L.
dc.contributor.authorDemirci, Şahin
dc.contributor.authorWypyski, Madison S.
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorBhethanabotla, Venkat R.
dc.contributor.authorLawson, Louise B.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T18:53:26Z
dc.date.available2025-01-27T18:53:26Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractProtonable polyethyleneimine (PEI) and citric acid (CA) based C-dots were prepared via a hydrothermal process, yielding particles with a hydrodynamic diameter of ~100 and ~80 nm, and zeta potential of ? 2.3 ± 0.1 and + 23.4 ± 0.2 mV for PEI-CA C-dots and their protonated form, respectively. Treating Staphylococcus aureus with these C-dots resulted in a statistically significant reduction in bacterial growth, specifically growth in the planktonic phase as well as in the development of bacterial biofilm when compared to untreated (p < 0.05). When 24 h matured S. aureus biofilms were treated with C-dots, a significant disruption and dispersion of bacteria from the existing biofilms was noted as compared to untreated (p < 0.05). Other Gram-positive microorganisms (B. cereus, S. epidermidis, S. pyogenes) and Gram-negative (P. mirabilis, E. coli, and P. aeruginosa) were also susceptible to the antimicrobial activity of the PEI-CA C-dots with significant inhibition of bacterial growth noted for all organisms after C-dot treatment. Only for B. cereus, S. epidermidis, and P. aeruginosa was this reduction in total growth reflected in decreased planktonic growth. However, biofilm formation by all organisms was reduced significantly upon treatment with the C-dots, including those for which planktonic growth was not impacted. © 2022 Elsevier B.V.
dc.description.sponsorshipTulane University; University of South Florida, USF
dc.identifier.doi10.1016/j.colsurfb.2022.112704
dc.identifier.issn0927-7765
dc.identifier.scopus2-s2.0-85134769227
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2022.112704
dc.identifier.urihttps://hdl.handle.net/20.500.12428/12712
dc.identifier.volume217
dc.identifier.wosWOS:000835140800004
dc.identifier.wosqualityQ1
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofColloids and Surfaces B: Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectAntibacterial surface; Antibiofilm; Bacterial eradication; Biofilm inhibition; Carbon dot
dc.titleBiofilm inhibition and bacterial eradication by C-dots derived from polyethyleneimine-citric acid
dc.typeArticle

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