Evaluation of Anti-Cytotoxicity and Anti-Genotoxicity of Raphanus sativus L. Tuber on Allium cepa L. Root Tips

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dc.authorid0000-0002-4206-1149en_US
dc.authorscopusid57190792661en_US
dc.authorwosidABF-2517-2020en_US
dc.contributor.authorKaya, Nergis
dc.date.accessioned2024-01-22T06:49:06Z
dc.date.available2024-01-22T06:49:06Z
dc.date.issued2023en_US
dc.departmentMeslek Yüksekokulları, Biga Meslek Yüksekokulu, Gıda İşleme Bölümü
dc.description.abstractAbstract: Raphanus sativus (radish) tuber extracts stock solutions were prepared by dissolving radish extracts prepared with certain solvents (distilled water, ethanol and methanol) in dimethyl sulfoxide. Negative control (dimethyl sulfoxide, DMSO), positive control mutagen (ethyl methanesulfonate) and R. sativus extracts (10 and 20 mg/mL doses) were applied to Allium cepa root tips at for 24 and 48 h. For examination under the light microscope, the root tips were placed in fixative, then hydrolyzed and treated with acetocarmine. Chromosomal aberration index (CAI%) was increased as compared with the negative control, but decreased as compared with the positive control after the application of three different extracts. It was put forward that mitotix index decreased with increasing extract concentration applications. In this way, it has been determined that these extracts have an inhibitory effect on cell division at high doses. It has been found that CAI% was an increase with increasing extract concentration. It has been revealed that distilled water, ethanol and methanol extracts have more inhibitory effect on cell division and an increasing frequency of chromosomal anomalies, respectively. As a result of this research, R. sativus tuber might cause damage to cells genetic material and spindle formation when used incorrectly.en_US
dc.identifier.citationKaya, N. (2023). Evaluation of Anti-Cytotoxicity and Anti-Genotoxicity of Raphanus sativus L. Tuber on Allium cepa L. Root Tips. Biology Bulletin, 50(3), 293–299. https://doi.org/10.1134/s1062359022601690 ‌en_US
dc.identifier.doi10.1134/s1062359022601690
dc.identifier.endpage299en_US
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85152451563
dc.identifier.startpage293en_US
dc.identifier.urihttps://doi.org/10.1134/s1062359022601690
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5268
dc.identifier.volume50en_US
dc.identifier.wosWOS:000967779800006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaya, Nergis
dc.language.isoen
dc.publisherPleiades Publishingen_US
dc.relation.ispartofBiology Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectPharmaceutical plant extracten_US
dc.subjectRaphanus sativus Len_US
dc.titleEvaluation of Anti-Cytotoxicity and Anti-Genotoxicity of Raphanus sativus L. Tuber on Allium cepa L. Root Tips
dc.typeArticle

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