Effects of kefir on ischemia-reperfusion injury

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.contributor.authorYener, A. U.
dc.contributor.authorSehitoglu, M. H.
dc.contributor.authorOzkan, M. T. A.
dc.contributor.authorBekler, A.
dc.contributor.authorEkin, A.
dc.contributor.authorCokkalender, O.
dc.contributor.authorDeniz, M.
dc.date.accessioned2025-01-27T20:41:19Z
dc.date.available2025-01-27T20:41:19Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOBJECTIVE: We aimed to investigate the effect of kefir on Ischemia-Reperfusion (I/R) injury on rats. MATERIALS AND METHODS: 24 male Sprague-Dawley rats between 250-350 g were selected. Rats were divided into three groups, and there were eight rats in each group. Rats were fed for 60 days. All of the rats were fed with the same diet for the first 30 days. In the second thirty days, kefir [10 cc/kg/day body weight (2 x 10(9) cfu/kg/day)] was added to the diet of the study group by gavage method. In all groups, lung and kidney tissues were removed after the procedure and rats were sacrificed. The biochemical and histopathological changes were observed in the lung and kidney within the samples. Serum urea, creatinine and tumor necrosis factor (TNF-alpha) were determined. RESULTS: Kefir + I/R groups was compared with I/R groups, a significant decrease (p < 0.05) was seen in Lipid peroxidation (MDA) levels of lung and renal tissues. Superoxide dismutase (SOD), Catalase (CAT) and Glutathione peroxidase (GSH-Px) activities of lung and kidney tissues decreased in I/R groups (p < 0.05). The enzyme activities in Kefir + I/R groups of renal tissues were significantly (p < 0.05) higher than I/R, not significantly different in lung tissues (p < 0.05). Kefir reduced the levels of serum urea, creatinine and TNF-alpha significantly. CONCLUSIONS: This would be useful in this model against ischemia/reperfusion, and shows the protective effect of kefir in tissue and serum functions.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects Commission [TSA-2014-135]
dc.description.sponsorshipThis study supported by Canakkale Onsekiz Mart University Scientific Research Projects Commission (no: TSA-2014-135).
dc.identifier.endpage896
dc.identifier.issn1128-3602
dc.identifier.issue5
dc.identifier.pmid25807443
dc.identifier.scopus2-s2.0-84942257383
dc.identifier.scopusqualityQ2
dc.identifier.startpage887
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24102
dc.identifier.volume19
dc.identifier.wosWOS:000352642700026
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectKefir
dc.subjectIschemia-reperfusion injury
dc.subjectLung
dc.subjectKidney
dc.titleEffects of kefir on ischemia-reperfusion injury
dc.typeArticle

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