Sensitive voltammetric determination of famotidine in human urine and tablet dosage forms using an ultra trace graphite electrode

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dc.authoridUslu, Bengi/0000-0002-7327-4913
dc.authoridOZKAN, Sibel/0000-0001-7494-3077
dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.contributor.authorYagmur, Sultan
dc.contributor.authorYilmaz, Selehattin
dc.contributor.authorSaglikoglu, Gulsen
dc.contributor.authorUslu, Bengi
dc.contributor.authorSadikoglu, Murat
dc.contributor.authorOzkan, Sibel A.
dc.date.accessioned2025-01-27T20:20:37Z
dc.date.available2025-01-27T20:20:37Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, the direct and sensitive determination of famotidine based on its electrochemical oxidation was investigated in spiked human urine and tablet dosage forms. The electrochemical measurements were performed in various buffer solutions in the pH range 0.88-12.08 at an ultra trace graphite electrode (UTGE) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The best results were obtained for the quantitative determination of famotidine by the DPV technique in 0.5 mol L-1 H2SO4 solution (pH 0.30). In this strong acid medium, one irreversible anodic peak was observed. The effects of pH and scan rate on the peak current and peak potential were investigated. The diffusion-controlled nature of the peak was established. For optimum conditions described in the experimental section, a linear calibration curve for DPV analysis was constructed in the famotidine concentration range 2x10(-6)-9x10(-5) mol L-1. The limit of detection (LOD) and limit of quantification (LOQ) were 3.73x10(-7) and 1.24x10(-6) mol L-1 at a UTGE, respectively. The repeatability, precision and accuracy of the developed technique were checked by recovery studies in spiked urine and tablet dosage forms.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [TBAG-2173, 102T062]
dc.description.sponsorshipThe authors gratefully acknowledge the Scientific and Technical Research Council of Turkey (TUBITAK, Grant No.: TBAG-2173; 102T062). The authors would like to thank Ilsan Inc. (Istanbul, Turkey) for supplying pure famotidine and its tablet dosage forms for the development of the proposed voltammetric technique.
dc.identifier.doi10.2298/JSC130210055Y
dc.identifier.endpage62
dc.identifier.issn0352-5139
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84893240227
dc.identifier.scopusqualityQ3
dc.identifier.startpage53
dc.identifier.urihttps://doi.org/10.2298/JSC130210055Y
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21767
dc.identifier.volume79
dc.identifier.wosWOS:000331780600005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSerbian Chemical Soc
dc.relation.ispartofJournal of The Serbian Chemical Society
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectfamotidine
dc.subjectvoltammetry
dc.subjectultra trace graphite electrode
dc.subjectdetermination
dc.subjecthuman urine
dc.subjectdosage forms
dc.titleSensitive voltammetric determination of famotidine in human urine and tablet dosage forms using an ultra trace graphite electrode
dc.typeArticle

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