Neuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia

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dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.contributor.authorSen, Halil Murat
dc.contributor.authorOzkan, Adile
dc.contributor.authorSalis, Osman
dc.contributor.authorSehitoglu, Ibrahim
dc.date.accessioned2025-01-27T20:22:27Z
dc.date.available2025-01-27T20:22:27Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). Cerebral ischemia was induced via intraluminal monofilament occlusion model. In all groups, the brain was removed after the procedure and rats were sacrificed. Malondialdehyde, superoxide dismutase and nuclear respiratory factor-1 were measured in the ischemic hemisphere. The histopathological changes were observed in the right hemisphere within the samples. Functional assessment was performed for neurological deficit scores. Results: Following the treatment, biochemical factors changed significantly. Histopathologically, it was shown that p-coumaric acid decreased the oxidative damage. The neurological deficit scores of p-coumaric acid-treated rats were significantly improved after cerebral ischemia. Conclusion: Our results showed that p-coumaric acid is a neuroprotective agent on account of its strong anti-oxidant and anti-apoptotic features. Moreover, p-coumaric acid decreased the focal ischemia. Extra effort should be made to introduce p-coumaric acid as a promising therapeutic agent to be utilized for treatment of human cerebral ischemia in the future.
dc.identifier.endpage363
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue4
dc.identifier.pmid26019798
dc.identifier.scopus2-s2.0-84929463444
dc.identifier.scopusqualityQ2
dc.identifier.startpage356
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21899
dc.identifier.volume18
dc.identifier.wosWOS:000354996400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMashhad Univ Med Sciences
dc.relation.ispartofIranian Journal of Basic Medical Sciences
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectCoumaric acids
dc.subjectIschemia
dc.subjectNeuroprotective agents
dc.subjectNuclear respiratory factor 1
dc.subjectRats
dc.titleNeuroprotective effect of p-coumaric acid in rat model of embolic cerebral ischemia
dc.typeArticle

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