Increased Expression of Matrix Metalloproteinases in Ligamentum Flavum Hypertrophy of the Patients with Lumbar Spinal Stenosis

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dc.contributor.authorEser, Betul
dc.contributor.authorEser, Olcay
dc.contributor.authorSimsek, Nejdet
dc.contributor.authorBulbul, Erdogan
dc.contributor.authorGuven, Mustafa
dc.date.accessioned2025-01-27T20:55:50Z
dc.date.available2025-01-27T20:55:50Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis paper shows an investigation of the expressions of MMP-3,-13 and their polymorphisms in patients with lumbar spinal stenosis (LSS). Hypertrophied LF tissues and peripheral bloods were obtained from 50 patients with LSS. The expressions of MMP-3,-13 and their polymorphisms were analyzed. No relationship was found between thickness of LFs and MMP-3,-13 genotypes. LF tissues were divided to three groups as grade 1, 2 and 3. Rich elastic fibrils were observed in grade 1. Elastic fibers and elastin/collagen rates decreased in grade 2-3 and 4, and collagen fibers increased and presented a cystic degeneration. MMP-3 immunopositive cells were higher than MMP-13. A correlation between LF thicknesses and MMP-3 was detected. Both MMP-3, -13 were expressed (MMP-3 in higher quantities) in high grade hypertrophied LF. The researchers expect that this paper would provide a better understanding of the pathogenesis of LF hypertrophy and lead to therapeutic alternatives for LSS patients.
dc.description.sponsorshipBalikesir University [2014/04]
dc.description.sponsorshipThe researchers would like to thank to Dr. A. Said Bodur for helping with the statistical analysis. This work was supported by the research fund of the Balikesir University (2014/04). This study was presented as a poster at The European Association of Neurosurgical Societies (EANS) Annual Meeting, Madrid, Spain, 2015.
dc.identifier.endpage9
dc.identifier.issn0972-3757
dc.identifier.issue1-2
dc.identifier.scopus2-s2.0-84978953895
dc.identifier.scopusqualityN/A
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26199
dc.identifier.volume16
dc.identifier.wosWOS:000381656300001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKamla-Raj Enterprises
dc.relation.ispartofInternational Journal of Human Genetics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectExpression
dc.subjectLigament
dc.subjectMetalloproteinase
dc.subjectPolymorphism
dc.subjectStenosis
dc.titleIncreased Expression of Matrix Metalloproteinases in Ligamentum Flavum Hypertrophy of the Patients with Lumbar Spinal Stenosis
dc.typeArticle

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