The pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma

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dc.contributor.authorKara, Medine
dc.contributor.authorUysal, Sema
dc.contributor.authorAltinisik, Ugur
dc.contributor.authorCevizci, Sibel
dc.contributor.authorGuclu, Oguz
dc.contributor.authorDerekoy, Fevzi Sefa
dc.date.accessioned2025-01-27T21:03:46Z
dc.date.available2025-01-27T21:03:46Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of this study was to identify the potential prognostic roles of the preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red cell distribution width (RDW) in patients with laryngeal squamous cell carcinoma (LSCC). 81 patients who underwent surgery for the larynx carcinoma were enrolled in the study. NLR, PLR and RDW were used as outcome measures. Local recurrence was detected in 30 (37.0 %) patients and neck lymph node metastasis was detected 6 (7.4 %) patients during follow-up period. Mortality was seen in 7 (8.6 %) patients. The mean PLR in the T1 and T2 stage tumors were significantly lower than the T4 stage. The mean RDW and PLR were significantly higher in the exitus group than the survivor group. The mean NLR in the patients with local recurrence was significantly higher than the non-recurrent patients. Progression-free survival (PFS) was lower in patients with high NLR. When analyzed by the Cox regression analysis of factors affecting the local recurrence, NLR was found to significantly affect the recurrence. According to ROC analysis for mortality, NLR was not found to be a prognostic factor, although the PLR and RDW were significant prognostic factors. According to Cox regression analysis, a high PLR increases mortality 4.2 times and a high RDW 4.6 times. Although in univariate analysis MCV, RDW and tumor grade were predictors of mortality, RDW and tumor grade independent predictors were found. Further studies involving large patient groups are required.
dc.identifier.doi10.1007/s00405-016-4250-8
dc.identifier.endpage542
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue1
dc.identifier.pmid27520567
dc.identifier.scopus2-s2.0-84982094924
dc.identifier.scopusqualityQ1
dc.identifier.startpage535
dc.identifier.urihttps://doi.org/10.1007/s00405-016-4250-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27443
dc.identifier.volume274
dc.identifier.wosWOS:000393599900067
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNeutrophil-to-lymphocyte ratio
dc.subjectPlatelet-to-lymphocyte ratio
dc.subjectRed cell distribution width
dc.subjectLarynx carcinoma
dc.subjectPrognosis
dc.titleThe pre-treatment neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and red cell distribution width predict prognosis in patients with laryngeal carcinoma
dc.typeArticle

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