Effects of Aloe Vera on Spinal Cord Ischemia-Reperfusion Injury of Rats

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dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridkaymaz, burak/0000-0001-6207-8063
dc.contributor.authorYuksel, Yasemin
dc.contributor.authorGuven, Mustafa
dc.contributor.authorKaymaz, Burak
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.contributor.authorTosun, Murat
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: The purpose of this study was to evaluate the possible protective/therapeutic effects of aloe vera (AV) on ischemia-reperfusion injury (I/R) of spinal cord in rats. Materials and Methods: A total of 28 Wistar Albino rats were divided into four random groups of equal number (n = 7). Group I (control) had no medication or surgery; Group II underwent spinal cord ischemia and was given no medication; Group III was administered AV by gastric gavage for 30days as pre-treatment; Group IV was administered single dose intraperitoneal methylprednisolone (MP) after the ischemia. Nuclear respiratory factor-1 (NRF1), malondialdehyde (MDA) and superoxide dismutase (SOD) levels were evaluated. Tissue samples were examined histopathologically and neuronal nitric oxide synthase (nNOS) and nuclear factor-kappa B (NF-B) protein expressions were assessed by immunohistochemical staining. Results: NRF1 and SOD levels of ischemia group were found to be lower compared to the other groups. MDA levels significantly increased after I/R. Treatment with AV and MP resulted in reduced MDA levels and also alleviated hemorrhage, edema, inflammatory cell migration and neurons were partially protected from ischemic injury. When AV treatment was compared with MP, there was no statistical difference between them in terms of reduction of neuronal damage. I/R injury increased NF-B and nNOS expressions. AV and MP treatments decreased NF-B and nNOS expressions.Conclusions: It was observed that aloe vera attenuated neuronal damage histopathologically and biochemically as pretreatment. Further studies may provide more evidence to determine the additional role of aloe vera in spinal cord ischemia reperfusion injury.
dc.identifier.doi10.1080/08941939.2016.1178358
dc.identifier.endpage398
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6
dc.identifier.pmid27142763
dc.identifier.scopus2-s2.0-84964999898
dc.identifier.scopusqualityQ1
dc.identifier.startpage389
dc.identifier.urihttps://doi.org/10.1080/08941939.2016.1178358
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23981
dc.identifier.volume29
dc.identifier.wosWOS:000388745000010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Investigative Surgery
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectspinal cord
dc.subjectischemia-reperfusion injury
dc.subjectAloe vera
dc.subjectmethylprednisolone
dc.subjectNRF1
dc.subjectSOD
dc.subjectMDA
dc.subjectnNOS
dc.subjectNF-B
dc.titleEffects of Aloe Vera on Spinal Cord Ischemia-Reperfusion Injury of Rats
dc.typeArticle

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