Primary cutaneous lymphomas: single center experience of dermatology and hematology clinics

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dc.contributor.authorPayzin, Bahriye
dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorYildirim, Aysegul Cidem
dc.contributor.authorDurur, Serap Ozturk
dc.contributor.authorSentekin, Serra
dc.date.accessioned2025-01-27T21:01:40Z
dc.date.available2025-01-27T21:01:40Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose: To present the clinical characteristics, treatments performed, response to treatment, and follow up of 40 patients diagnosed with primary cutaneous lymphoma. Methods: In this retrospective study included were 23 males and 17 females from our center with confirmed diagnosis of primary cutaneous lymphoma over an 8-year period. Data were retrieved from the patient medical records. Results: The median patient age at diagnosis was 59.5 years (range 33-86). Skin biopsies showed that 31 patients (77.5%) had mycosis fungoides (MF), 2 (5%) had anaplastic large cell lymphoma, 3 (7.5%) had diffuse large B cell lymphoma, 3 (7.5%) had poikilodermic mycosis fungoides, and 1 (2.5%) had non-classified non-Hodgkin lymphoma (NHL). In patients with T cell lymphoma clinical stage IA prevailed (42.5%). The 3 patients with B cell lymphoma had stage IE and 2 of them had B symptoms. Sezary cells were detectable in the peripheral blood of 3 patients. Twenty-three patients (57.5%) used only topical corticosteroids, 2 (5%) were treated with PUVA (psoralen ultraviolet A), 1 (2.5%) was treated with PUVA and chemotherapy, 8(20%) received combination chemotherapy, 1 patient (2.5%) received PUVA+interferon+topical nitrogen mustard, and 1 (2.5%) received chemotherapy+topical nitrogen mustard+interferon. Among 16 patients whith evaluable response to treatment 5 (33%) showed complete remission (CR) and 9 (60%) partial remission (PR). The median follow up time for all patients was 1.5 months (range 1-135). While mean overall survival (OS) time was 123 months (95% Cl 100.6-145.3), the estimated median OS was not reached. Conclusion: Early diagnosis of MF is rather favorable in terms of high and long-term response rates to topical treatments.
dc.identifier.endpage177
dc.identifier.issn1107-0625
dc.identifier.issn2241-6293
dc.identifier.issue1
dc.identifier.pmid24659660
dc.identifier.scopus2-s2.0-84898921153
dc.identifier.scopusqualityN/A
dc.identifier.startpage171
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27142
dc.identifier.volume19
dc.identifier.wosWOS:000334153000025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImprimatur Publications
dc.relation.ispartofJournal of Buon
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectmycosis fungoides
dc.subjectprimary cutaneous lymphoma
dc.subjectprimary cutaneous lymphoma
dc.subjectSezary cells
dc.titlePrimary cutaneous lymphomas: single center experience of dermatology and hematology clinics
dc.typeArticle

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