Electrochemical bioplatform for the determination of the most common and carcinogenic dibutyl phthalate migrated from daily-use plastic products

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dc.contributor.authorAydin, Elif Burcu
dc.contributor.authorAydin, Muhammet
dc.contributor.authorSezginturk, Mustafa Kemal
dc.date.accessioned2026-02-03T12:03:04Z
dc.date.available2026-02-03T12:03:04Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDibutyl phthalate (DBP) is a typical plasticizer used in the production and processing of plastic items. Given that DBP is easily leached and discharged into the environment, posing a threat to nature and living things, a facile and feasible impedimetric magneto biosensor for ultrasensitive determination of DBP was constructed first of all by using epoxy-functionalized magnetic nanoparticles as a sensing platform. A magnetic field on the electrode surface kept the epoxy-functionalized magnetic nanoparticles in place, and the particular interaction was conducted on the solid platform of magnetic nanoparticles. This sensing platform with a large surface area enhanced to attach a large amount of DBP-specific aptamer leads to a further increase in the sensitivity of the aptasensor. The DBP-specific aptamer was covalently attached to the epoxy groups of the 3-(glycidoxypropyl)trimethoxysilane (GPMS) agent standing at the magnetic nanoparticle surface without using any crosslinking agent. Meanwhile, the DBP aptamer attached to the as-prepared epoxy-functionalized magnetic nanoparticles via amide bonds specifically recognized the DBP analyte. The interactions of DBP with the aptamer on the epoxy-functionalized magnetic nanoparticles were studied by different electrochemical techniques, and for the quantification of DBP, electrochemical impedance spectroscopy (EIS) was utilized. In the best conditions, the electrochemical aptasensor showed good results for measuring DBP, with a broad range from 1 to 200 pg/mL and a very low detection limit (LOD) of 0.32 pg/mL. Importantly, the resulting aptasensor had excellent repeatability and reproducibility, desirable specificity, long storage stability, and high sensitivity, indicating its potential applications in food and environmental safety. In addition, the real sample experiments performed on the daily-use plastic products revealed the feasibility of the proposed detection approach.
dc.description.sponsorshipScientific and Technological Research Council of Tekirdag Namimath;k Kemal University [NKUBAP.00.GA.24.600]
dc.description.sponsorshipScientific and Technological Research Council of Tekirdag Nam & imath;k Kemal University, NKUBAP.00.GA.24.600.
dc.identifier.doi10.1007/s00604-025-07418-0
dc.identifier.issn0026-3672
dc.identifier.issn1436-5073
dc.identifier.issue8
dc.identifier.pmid40750691
dc.identifier.scopus2-s2.0-105012474337
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1007/s00604-025-07418-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34964
dc.identifier.volume192
dc.identifier.wosWOS:001542626300002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofMicrochimica Acta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectPhthalate esters
dc.subjectDibutyl phthalate
dc.subjectImpedimetric aptasensor
dc.subjectMagneto-sensing
dc.titleElectrochemical bioplatform for the determination of the most common and carcinogenic dibutyl phthalate migrated from daily-use plastic products
dc.typeArticle

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