Adsorptive stripping voltammetric determination of zopiclone in tablet dosage forms and human urine

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dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.contributor.authorYilmaz, Selehattin
dc.date.accessioned2025-01-27T21:13:03Z
dc.date.available2025-01-27T21:13:03Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAdsorptive stripping voltammetric(AdSV) techniques were proposed for the direct quantitative determination of zopiclone (ZP) in spiked human urine and tablet dosage forms for first time. The electrochemical oxidation and determination of ZP were easily carried Out on glassy carbon electrode (CGE) using a variety of voltammetric techniques. Different conditions were investigated to optimize the analytical determination of ZP. The dependence of the intensities of currents and potentials oil pH, concentration, scan rate, deposition time, deposition potential, and nature of the buffer were investigated. Oxidation of ZP was found to be adsorptive-controlled and irreversible. The best results for the determination of ZP were obtained by using differential pulse adsorptive stripping (DPAdSV) and osteryoung square wave voltammetric (OSWAdSV) techniques in Britton-Robinson buffer at pH 7.08 after a pre-concentration period of 120s at 0.60V. The peak Current showed a linear dependence oil the ZP concentration in the range of 6 x 10(-7) to 2 x 10(-5) mol L(-1) for both techniques. The achieved limits of detection and quantitation were 2.78 x 10(-7) and 5.28 x 10(-7) mol L(-1) for DPAdSV; 1.70 x 10(-7) and 5.78 x 10(-7) mol L(-1) for OSWAdSV, respectively. The proposed techniques were successfully applied to direct determination of ZP in tablet dosage form and spiked human urine samples. Excipients did not interfere with the determination. Precision and accuracy of the developed method were checked by recovery studies in tablet dosage forms and spiked urine samples. (C) 2009 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technical Research Council of Turkey [TBAG-2173, 102T062]
dc.description.sponsorshipThe author gratefully acknowledges to the Scientific and Technical Research Council of Turkey (TUBITAK Grant No.: TBAG-2173; 102T062). The author would also like to thank Eczacibasi, Inc. (Istanbul, Turkey) for supplying pure ZP and its commercial tablet forms for developing proposed voltammetric technique. We would like to thank to Kenan Dikilitas, the teaching staff at Language and Literature Department at Canakkale Onsekiz Mart University for providing help with the language used in the study.
dc.identifier.doi10.1016/j.colsurfb.2009.01.007
dc.identifier.endpage83
dc.identifier.issn0927-7765
dc.identifier.issue1
dc.identifier.pmid19201168
dc.identifier.scopus2-s2.0-64849099947
dc.identifier.scopusqualityQ1
dc.identifier.startpage79
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2009.01.007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28261
dc.identifier.volume71
dc.identifier.wosWOS:000266023600011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectZopiclone
dc.subjectAdsorptive stripping voltammetry
dc.subjectDetermination
dc.subjectGlassy carbon electrode
dc.subjectHuman urine
dc.subjectTablet dosage forms
dc.titleAdsorptive stripping voltammetric determination of zopiclone in tablet dosage forms and human urine
dc.typeArticle

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