Synthesis of new type temperature and pH sensitive hydrogels using drug-based p-(methacryloyloxy)acetanilide monomer and their usage as controlled drug carrier material

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dc.authoridOzay, Hava/0000-0002-4184-7801
dc.contributor.authorGungor, Zeynep
dc.contributor.authorOzay, Hava
dc.date.accessioned2025-01-27T20:55:46Z
dc.date.available2025-01-27T20:55:46Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn our study, as a functional monomer, p-(methacryloyloxy)acetanilide (MOAA) was synthesized and utility in hydrogel systems with various commercial monomers after the structural characterization was analyzed. In terms of temperature sensitivity and suitability for use in biological applications, N-isopropyl acrylamide (NIPAm) monomer and pH-sensitive acrylic acid (AAc) monomer were chosen among the commercial monomers. To the best of our knowledge, p(N-isopropyl acrylamide-co-p-(p-methacryloyloxy)acetanilide) (GEL 5) and p(N-isopropyl acrylamide-co-acrylic acid-co-p-(p-methacryloyloxy)acetanilide) (GEL 8) were synthesized in the form of a film with the free radical polymerization technique for first time in the literature. The structural characterizations and surface morphologies of the hydrogels p(NIPAm) (GEL 1), p(NIPAm-co-MOAA) (GEL 5), and p(NIPAm-co-AAc-co-MOAA) (GEL 8) were investigated by using the techniques of FTIR spectroscopy and scanning electron microscope (SEM). Moreover, the thermal resistance of all three hydrogels was brightened by the thermal gravimetric analysis (TGA). Swelling behaviors in different environments of the MOAA-based hydrogels, prepared as pH and temperature-sensitive, were examined, and biomedical applications are occurred by the investigation of the usability as a controlled drug delivery material. For this purpose, sodium diclofenac (NaDc) drug, used in pain and inflammation treatment, was chosen. In vitro release of NaDc from the drug-loaded hydrogel was examined in pH 5.5 (PBS) and pH 7.4 (PBS) media. Korsmeyer-Peppas model was used in defining the drug release mechanism.
dc.description.sponsorshipTurkish Higher Education Council (YoK)'s 100/2000 PhD fellowship program
dc.description.sponsorshipThis study is derived from a part of Zeynep Gungor's PhD thesis. Zeynep Gungor is thankful to the Turkish Higher Education Council (YoK)'s 100/2000 PhD fellowship program for supporting.
dc.identifier.doi10.1080/10601325.2022.2028552
dc.identifier.endpage306
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85123435539
dc.identifier.scopusqualityQ2
dc.identifier.startpage295
dc.identifier.urihttps://doi.org/10.1080/10601325.2022.2028552
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26172
dc.identifier.volume59
dc.identifier.wosWOS:000744735000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectN-isopropyl acrylamide
dc.subjectacrylic acid
dc.subjectpH-sensitive
dc.subjecttemperature sensitive
dc.subjecthydrogel
dc.subjectcontrolled release
dc.titleSynthesis of new type temperature and pH sensitive hydrogels using drug-based p-(methacryloyloxy)acetanilide monomer and their usage as controlled drug carrier material
dc.typeArticle

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