Colloidal drug carries from (sub)micron hyaluronic acid hydrogel particles with tunable properties for biomedical applications

Basit Öğe Kaydı
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridJohn, Vijay/0000-0001-5426-7585
dc.authoridAktas, Nahit/0000-0001-9341-607X
dc.authoridŞahiner, Nurettin/0000-0003-0120-530X
dc.contributor.authorIlgin, Pinar
dc.contributor.authorAvci, Gulden
dc.contributor.authorSılan, Coşkun
dc.contributor.authorEkici, Sema
dc.contributor.authorAktas, Nahit
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorJohn, Vijay T.
dc.date.accessioned2025-01-27T20:43:47Z
dc.date.available2025-01-27T20:43:47Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHyaluronic acid (HA) hydrogel particles were synthesized in a single step employing water-in-oil microemulsion system. The HA particles were formed in the micro-environments of aqueous HA solution in oil by chemical crosslinking with divinyl sulfone (DVS). To produce magnetic field responsive HA-composite particles, iron magnetic nanoparticles were introduced into microemulsion system during synthesis to obtain HA-magnetic composites. For this purpose, iron nanoparticles were separately synthesized and mixed with linear HA followed by chemical crosslinking of linear HA with DVS in the micro-environments to envelope magnetic metal nanoparticles in the emulsion system. Scanning electron microscopy (SEM), dynamic light scattering (DLS) studies, and zeta potentials measurement were performed for particle size, charge and morphological characterization. Additionally. HA particles were chemically modified to induce desired functional groups on the particle surface and utilized for potential drug delivery vehicles. Trimethoprim (TMP) a bacteriostatic antibiotic drug were used as a model drug for the release studies in phosphate buffer solution (PBS) at pH 7.4 from bare HA, magnetic HA-composite and modified HA hydrogel particles. (C) 2010 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technical Research Council of Turkey [108T133]; Turkish Academy of Science
dc.description.sponsorshipThis work is supported by The Scientific and Technical Research Council of Turkey (Grant No. 108T133). N. Sahiner is also grateful to Turkish Academy of Science for the support under 2008, TUBA-GEBIP program.
dc.identifier.doi10.1016/j.carbpol.2010.06.033
dc.identifier.endpage1003
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.issue3
dc.identifier.scopus2-s2.0-77955657977
dc.identifier.scopusqualityQ1
dc.identifier.startpage997
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2010.06.033
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24371
dc.identifier.volume82
dc.identifier.wosWOS:000281524900067
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectComposites
dc.subjectMagnetic particles
dc.subjectDelivery
dc.subjectBiomaterial
dc.subjectHyaluronic acid
dc.titleColloidal drug carries from (sub)micron hyaluronic acid hydrogel particles with tunable properties for biomedical applications
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu