Targeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAs

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dc.authorid0000-0003-4056-1673
dc.authorid0000-0002-0213-9087
dc.contributor.authorJavadifar, Amin
dc.contributor.authorTahani, Masoud
dc.contributor.authorKhayat, Sorousha
dc.contributor.authorNasab, Shiva Rakhshani
dc.contributor.authorKarav, Sercan
dc.contributor.authorKesharwani, Prashant
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2026-02-03T12:02:41Z
dc.date.available2026-02-03T12:02:41Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMitophagy, a selective form of autophagy, plays an indispensable role in preserving mitochondrial integrity by eliminating dysfunctional mitochondria, thereby sustaining cellular homeostasis. This process is particularly critical in cardiomyocytes, which rely heavily on high-quality mitochondria to meet their substantial energy demands. Impaired mitophagy has been implicated in the pathogenesis of various cardiovascular diseases, including ischemic heart disease, heart failure, and cardiomyopathy. Emerging evidence highlights the pivotal regulatory role of microRNAs (miRNAs)-small non-coding RNA molecules-in modulating mitophagy by targeting key genes such as PINK1, Parkin, and FUNDC1, which are integral to mitochondrial quality control. This review comprehensively examines the dual capacity of miRNAs to either enhance or suppress mitophagy and evaluates the implications of these regulatory actions for cardiovascular health. For instance, miRNAs such as miR-24-3p and miR-125a-5p modulate mitophagy pathways, influencing cardiac function in distinct ways. Additionally, miRNAs like miR-34a and miR-330-3p may exert broader effects on mitochondrial homeostasis in cardiac tissue. This paper further explores the therapeutic potential of targeting miRNAs to restore mitophagy equilibrium and mitigate mitochondrial dysfunction, offering novel avenues for cardiovascular disease management. By synthesizing recent findings, this review underscores the promise of miRNA-based interventions and identifies critical directions for future research.
dc.identifier.doi10.1016/j.mad.2025.112082
dc.identifier.issn0047-6374
dc.identifier.issn1872-6216
dc.identifier.pmid40482727
dc.identifier.scopus2-s2.0-105007311337
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.mad.2025.112082
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34822
dc.identifier.volume226
dc.identifier.wosWOS:001509062000002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofMechanisms of Ageing and Development
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectMitophagy
dc.subjectCardiovascular diseases
dc.subjectMicroRNAs
dc.subjectMitochondrial quality control
dc.subjectCardiac health
dc.subjectTherapeutic targets
dc.titleTargeting mitophagy in the heart: Exploring the therapeutic potential of MicroRNAs
dc.typeArticle

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