Can magnetic resonance spectroscopy adequately differentiate neoplastic from non-neoplastic and low-grade from high-grade lesions in brain masses?

Basit Öğe Kaydı
dc.contributor.authorKarata?, Ozan
dc.contributor.authorKarata?, Gülden Yenice
dc.contributor.authorUysal, Ender
dc.contributor.authorCan, S.Meltem
dc.contributor.authorErtürk, Mehmet
dc.contributor.authorBaşak, Muzaffer
dc.date.accessioned2025-01-27T19:04:16Z
dc.date.available2025-01-27T19:04:16Z
dc.date.issued2010
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The aim of this study was to evaluate the usefulness of Magnetic Resonance Spectroscopy in the differential diagnosis of brain lesions. Materials and Methods: Forty-six patients with cerebral lesions were examined by Magnetic Resonance Spectroscopy. Choline, creatine, N-acetyl aspartate and lipid-lactate peaks were evaluated. Forty of the 46 patients underwent stereotactic biopsy or surgery. Histopathological results were compared with the Magnetic Resonance Spectroscopy results. Results: The Choline / N- acetyl aspartate ratio had the highest sensitivity (87.2%) in neoplastic versus nonneoplastic differentiation and the specificities of the Choline / Creatine, Choline / N-acetyl aspartate and Choline+Creatine / N-acetyl aspartate ratios were found to be 100%. Choline / Creatine ratios showed the highest sensitivity (95.7%) in low-grade versus high-grade differentiation and specificities of Choline / Nacetyl aspartate, Choline+Creatine / N- acetyl aspartate ratios and lipid-lactate levels were found to be 100%. Consequently, a value of Choline / Creatine > 2.2 and an accompanying lipid-lactate peak differentiated neoplasms as low-grade versus high-grade with a sensitivity of 100% (82.2-100%) and a specificity of 100% (71.7-100%). Conclusion: The presence of elevated Choline and decreased N-acetyl aspartate levels are effective in the differetiation of neoplastic versus non-neoplastic lesions with high sensitivity and specificity. A proposed ratio of Choline / Creatine > 2.2 and an accompanying lipid-lactate peak provide valuable information in differentiating low-grade from high-grade lesions.
dc.identifier.endpage338
dc.identifier.issn1019-1941
dc.identifier.issue3
dc.identifier.scopus2-s2.0-78649743350
dc.identifier.scopusqualityQ4
dc.identifier.startpage326
dc.identifier.trdizinid117390
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/117390
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13886
dc.identifier.volume23
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofMarmara Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subjectBrain neoplasms; Magnetic resonance imaging; Magnetic resonance spectroscopy; Stereotactic biopsy
dc.titleCan magnetic resonance spectroscopy adequately differentiate neoplastic from non-neoplastic and low-grade from high-grade lesions in brain masses?
dc.title.alternativeBeyİn kİtlelerİnde neoplastİk / neoplastİk olmayan ve yüksek evre / düşük evre ayriminda mr spektroskopİnİn yerİ
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu