ESI-IM-MS characterization of cyclodextrin complexes and their chemically cross-linked alpha (α-), beta (β-) and gamma (γ-) cyclodextrin particles as promising drug delivery materials with improved bioavailability

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorYılmaz, Aynur Sanem
dc.contributor.authorÖztürk, Serhat
dc.contributor.authorSalih, Bekir
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:16:40Z
dc.date.available2025-01-27T20:16:40Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCyclodextrins (CDs) are natural cyclic oligosaccharides with a relatively hydrophobic cavity and a hydrophilic outer surface. In this study, alpha (alpha-), beta (beta-) and gamma (gamma-) CD particles were prepared by directly using alpha-, beta-, and gamma-CDs as monomeric units and divinyl sulfone (DVS) as a crosslinker in a single-step via reverse micelle microemulsion crosslinking technique. Particles of p(alpha-CD), p(beta-CD), and p(gamma-CD) were perfectly spherical in sub 10 mu m size ranges. The prepared p(CD) particles at 1.0 mg/mL concentrations were found biocompatible with > 95 % cell viability against L929 fibroblasts. Furthermore, p(alpha-CD) and p(beta-CD) particles were found non-hemolytic with < 2 % hemolysis ratios, whereas p(gamma-CD) particles were found to be slightly hemolytic with its 2.1 +/- 0.4 % hemolysis ratio at 1.0 mg/mL concentration. Furthermore, a toxic compound, Bisphenol A (BPA) and a highly antioxidant polyphenol, curcumin (CUR) complexation with alpha-, beta-, and gamma-CD molecules was investigated via Electrospray-Ion Mobility-Mass Spectrometry (ESI-IM-MS) and tandem mass spectrometry (MS/MS) analysis. It was determined that the most stable noncovalent complex was in the case of beta-CD, but the complex stoichiometry was changed by the hydrophobic nature of the guest molecules. In addition, BPA and CUR were separately loaded into prepared p(CD) particles as active agents. The drug loading and release studies showed that p (CD) particles possess governable loading and releasing profiles.
dc.description.sponsorshipDepartment of Ophthalmology; Turkish Academy of Sciences (TUBA)
dc.description.sponsorshipThe Startup fund from the Department of Ophthalmology (N. Sahiner) is greatly appreciated. Also, the support from Turkish Academy of Sciences (TUBA) for B. Salih is greatly appreciated.
dc.identifier.doi10.1016/j.colsurfb.2023.113522
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid37657404
dc.identifier.scopus2-s2.0-85169832061
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2023.113522
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21342
dc.identifier.volume230
dc.identifier.wosWOS:001073226800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectalpha-, beta-, gamma- Cyclodextrin particles
dc.subjectInclusion complex
dc.subjectBisphenol A
dc.subjectCurcumin
dc.subjectMicrostructure
dc.titleESI-IM-MS characterization of cyclodextrin complexes and their chemically cross-linked alpha (α-), beta (β-) and gamma (γ-) cyclodextrin particles as promising drug delivery materials with improved bioavailability
dc.typeArticle

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