Methylenetetrahydrofolate Reductase Gene Germ-Line C677T and A1298C SNPs are Associated with Colorectal Cancer Risk in the Turkish Population

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dc.contributor.authorOzen, Filiz
dc.contributor.authorSen, Metin
dc.contributor.authorOzdemir, Ozturk
dc.date.accessioned2025-01-27T20:51:59Z
dc.date.available2025-01-27T20:51:59Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractColorectal cancer (CRC) is the third most common cause of death due to cancer in the worldwide and the incidence is also increasing in Turkey. Our present aim was to investigate any association between germ-line methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms and CRC risk in Turkey. A total of 86 CRC cases and 212 control individuals of the same ethnicity were included in the current study. Peripheral blood-DNA samples were used for genotyping by StripAssay technique, based on the reverse-hybridization principle and real-time PCR methods. Results were compared in Pearson Chi-square and multiple logistic regression models. The MTHFR 677TT (homozygous) genotype was found in 20.9% and the T allele frequency 4.2-fold increased in CRC when compared with the control group. The second SNP MTHFR 1298CC (homozygous) genotype was found in 14.0% and the C allele frequency 1.4-fold elevated in the CRC group. The current data suggest strong associations between both SNPs of germ-line MTHFR 677 C>T and 1298 A>C genotypes and CRC susceptibility in the Turkish population. Now the results need to be confirmed with a larger sample size.
dc.identifier.doi10.7314/APJCP.2014.15.18.7731
dc.identifier.endpage7735
dc.identifier.issn1513-7368
dc.identifier.issue18
dc.identifier.pmid25292054
dc.identifier.scopus2-s2.0-84908019132
dc.identifier.scopusqualityQ3
dc.identifier.startpage7731
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.18.7731
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25611
dc.identifier.volume15
dc.identifier.wosWOS:000343833600037
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectMTHFR gene
dc.subjectSNPs
dc.subjectC677T and A1298C
dc.subjectcolorectal cancer risk
dc.subjectTurkey
dc.titleMethylenetetrahydrofolate Reductase Gene Germ-Line C677T and A1298C SNPs are Associated with Colorectal Cancer Risk in the Turkish Population
dc.typeArticle

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