Electroanalytical Investigation of Paracetamol on Glassy Carbon Electrode by Voltammetry

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dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.contributor.authorEngin, C.
dc.contributor.authorYilmaz, S.
dc.contributor.authorSaglikoglu, G.
dc.contributor.authorYagmur, S.
dc.contributor.authorSadikoglu, M.
dc.date.accessioned2025-01-27T21:01:37Z
dc.date.available2025-01-27T21:01:37Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAn electroanalytical method was developed for the direct quantitative determination of paracetamol (or acetaminophen) in tablet dosage forms based on its oxidation behavior. The electrochemical oxidation and determination of paracetamol were easily carried out on glassy carbon electrode (GCE) using a variety of voltammetric techniques. The electrochemical measurements were carried out on GCE in various buffer solutions in the pH range from 0.51 to 12.00 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. The dependence of pH on the anodic peak current and peak potential was investigated. Acetate buffer (pH 4.51) was selected for analytical purposes. Scan rate studies were also completed. The diffusion controlled nature of the peak was established. A linear calibration curve for DPV analysis was constructed in the paracetamol concentration range from 4x10(-6) mol/L to 1x10(-4) mol/L. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 3.69x10(-7) mol/L and 1.23x10(-6) mol/L respectively. Validation of applied voltammetric techniques was checked with recovery studies.
dc.identifier.endpage1926
dc.identifier.issn1452-3981
dc.identifier.issue2
dc.identifier.startpage1916
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27122
dc.identifier.volume10
dc.identifier.wosWOS:000348365800070
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherEsg
dc.relation.ispartofInternational Journal of Electrochemical Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVoltammetric determination
dc.subjectdrug forms
dc.subjectglassy carbon electrode
dc.subjectparacetamol
dc.subjectvoltammetry
dc.titleElectroanalytical Investigation of Paracetamol on Glassy Carbon Electrode by Voltammetry
dc.typeArticle

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