The effects of type-I collagen membrane, hydroxyapatite, and platelet-rich plasma on bone regeneration: An experimental study

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dc.contributor.authorGenç, Çiğdem Çetin
dc.contributor.authorGulsun, Belgin
dc.date.accessioned2025-01-27T19:38:39Z
dc.date.available2025-01-27T19:38:39Z
dc.date.issued2021
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Various methods have been developed to support bone\rreconstruction, including the use of autogenous, allogenic, and synthetic\rbone graft substitutes, membranes, and concentrated supplements. This\rstudy aims to compare the effects of collagen membrane, hydroxyapatite,\rand platelet-rich plasma on the bone regeneration process in a rat model.\rMethodology: The experiment was conducted with 60 female Wistar\ralbino rats. Subjects were divided randomly into three groups (n: 20). In\rthe first group, the right femurs' defects were left empty (group I), and\rtype-I collagen membrane was applied to the left femurs (group II). TypeI collagen membrane + hydroxyapatite (group III) was applied to the second\rgroup, and type-I collagen membrane + hydroxyapatite + platelet-rich\rplasma (PRP) (group IV) was applied to the third group. Thus, a total of 80\rfemurs were included in the study, and defects were evaluated\rhistologically on the 10th, 21st, 45th, and 90th days (n: 5).\rResults: Groups II and III had better osteogenesis scores than group I,\rwhereas group IV had better results than all other groups.\rConclusion: In the PRP group, the osteogenesis scores were significantly\rbetter than the other groups. However, the healing was almost excellent\rin all three study groups (groups II, III, and IV) at the end of the\rexperiment
dc.identifier.doi10.5577/intdentres.2021.vol11.suppl1.16
dc.identifier.endpage102
dc.identifier.issn2146-1767
dc.identifier.issueSupplement 1
dc.identifier.startpage96
dc.identifier.trdizinid516756
dc.identifier.urihttps://doi.org/10.5577/intdentres.2021.vol11.suppl1.16
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/516756
dc.identifier.urihttps://hdl.handle.net/20.500.12428/17314
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofInternational Dental Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectHücre ve Doku Mühendisliği
dc.titleThe effects of type-I collagen membrane, hydroxyapatite, and platelet-rich plasma on bone regeneration: An experimental study
dc.typeArticle

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