The effects of type-I collagen membrane, hydroxyapatite, and platelet-rich plasma on bone regeneration: An experimental study
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Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Various methods have been developed to support bone\rreconstruction, including the use of autogenous, allogenic, and synthetic\rbone graft substitutes, membranes, and concentrated supplements. This\rstudy aims to compare the effects of collagen membrane, hydroxyapatite,\rand platelet-rich plasma on the bone regeneration process in a rat model.\rMethodology: The experiment was conducted with 60 female Wistar\ralbino rats. Subjects were divided randomly into three groups (n: 20). In\rthe first group, the right femurs' defects were left empty (group I), and\rtype-I collagen membrane was applied to the left femurs (group II). TypeI collagen membrane + hydroxyapatite (group III) was applied to the second\rgroup, and type-I collagen membrane + hydroxyapatite + platelet-rich\rplasma (PRP) (group IV) was applied to the third group. Thus, a total of 80\rfemurs were included in the study, and defects were evaluated\rhistologically on the 10th, 21st, 45th, and 90th days (n: 5).\rResults: Groups II and III had better osteogenesis scores than group I,\rwhereas group IV had better results than all other groups.\rConclusion: In the PRP group, the osteogenesis scores were significantly\rbetter than the other groups. However, the healing was almost excellent\rin all three study groups (groups II, III, and IV) at the end of the\rexperiment
Açıklama
Anahtar Kelimeler
Tıbbi Araştırmalar Deneysel, Hücre ve Doku Mühendisliği
Kaynak
International Dental Research
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
Supplement 1
