Bioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae)

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dc.authoridNahar, Prof Lutfun/0000-0002-1157-2405
dc.authoridShoeb, Mohammad/0000-0002-9486-2749
dc.authoridKong Thoo Lin, Paul/0000-0002-7090-246X
dc.authoridJaspars, Marcel/0000-0002-2426-6028
dc.contributor.authorShoeb, M.
dc.contributor.authorMacmanus, S. M.
dc.contributor.authorKong-Thoo-Lin, P.
dc.contributor.authorCelik, S.
dc.contributor.authorJaspars, M.
dc.contributor.authorNahar, L.
dc.contributor.authorSarker, S. D.
dc.date.accessioned2025-01-27T20:57:42Z
dc.date.available2025-01-27T20:57:42Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCentaurea pamphylica Boiss. & Heldr. (Family: Asteraceae), commonly known as 'pamphylia daisy', is a Turkish endemic species of the genus Centaurea that comprises ca. 500 species, many of which have been used as traditional medicines. The n-hexane, dichloromethane (DCM) and methanol (MeOH) extracts of the aerial parts of C. pamphylica were assessed for antioxidant activity and general toxicity using, respectively, the 2,2-diphenyl-l-picrylhydrazy] (DPPH), and the brine shrimp lethality assays. The reversed-phase preparative HPLC and PTLC were used to isolate compounds from the extracts. The structures of these compounds [1-4] were elucidated by spectroscopic means, and also by direct comparison with the respective published data. Both the DCM and the MeOH extract showed significant levels of antioxidant activities with the RC50 values of 72.6 x 10(-2) and 47.3 x 10-2 mg/mL, respectively. The MeOH extract exhibited low levels of toxicity towards brine shrimps (LD50 = 125.0 x 10(-2) mg/mL). Three major bioactive components of the MeOH extract were matairesinoside [1], arctim [21 and matairesinol [3]. An eudesmane-type sesquiterpene, pterodontriol [4], was also isolated from the DCM extract. Since reactive oxygen species are important contributors to various ailments, the antioxidant properties of the extracts as well as the isolated compounds may be of medicinal significance. This is the first report on the occurrence of 1-4 in C. pamphylica, and 4 in the genus Centaurea.
dc.identifier.endpage122
dc.identifier.issn1560-8115
dc.identifier.issue3
dc.identifier.scopus2-s2.0-35848946143
dc.identifier.scopusqualityQ1
dc.identifier.startpage118
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26455
dc.identifier.volume15
dc.identifier.wosWOS:000251273400001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTehran Univ Medical Sciences
dc.relation.ispartofDaru-Journal of Faculty of Pharmacy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCentaurea pamphylica
dc.subjectAsteraceae
dc.subjectlignan
dc.subjectDPPH
dc.subjectbrine shrimp lethality assay
dc.titleBioactivity of the extracts and isolation of lignans and a sesquiterpene from the aerial parts of Centaurea pamphylica (Asteraceae)
dc.typeArticle

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