Association of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorHiz, Meliha Merve
dc.contributor.authorSılan, Fatma
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:22:55Z
dc.date.available2025-01-27T20:22:55Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory skin disease. Although, the molecular mechanism is not completely understood, psoriasis is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of endothelial nitric oxide synthase (eNOS Glu298Asp) gene polymorphism in hypertensive and/or non-hypertensive psoriatic patients (2) to investigate the possible relationship between the eNOS Glu298Asp polymorphism and the risk of hypertension among psoriatic patients in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in Canakkale, Turkey PATIENTS AND METHODS: Gene profiles of 75 psoriatic patients (21 hypertensive and 54 normotensive patients) and 55 healthy (normotensive and non-psoriatic) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for patients and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0, Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS Glu298Asp single-nucleotide polymorphism (SNP) was determined in psoriatic patients when compared with normotensive non-psoriatic healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in hypertensive psoriatic patients when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive psoriatic patients (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS Glu298Asp polymorphism and hypertension among psoriatic patients in the Turkish population. The T allele frequency of eNOS Glu298Asp SNP was different in hypertensive psoriatic patients, and the difference was statistically significant when compared with the normotensive psoriatic patients and healthy controls. These results need to be confirmed by large-scale studies.
dc.description.sponsorshipScientific Research Center of Canakkale Onsekiz Mart University [BAP-2011/181]
dc.description.sponsorshipThe current research project was funded by the Scientific Research Center of Canakkale Onsekiz Mart University (BAP-2011/181).
dc.identifier.doi10.5144/0256-4947.2014.340
dc.identifier.endpage345
dc.identifier.issn0256-4947
dc.identifier.issn1319-9226
dc.identifier.issue4
dc.identifier.pmid25811208
dc.identifier.scopus2-s2.0-84926620945
dc.identifier.scopusqualityQ2
dc.identifier.startpage340
dc.identifier.urihttps://doi.org/10.5144/0256-4947.2014.340
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22068
dc.identifier.volume34
dc.identifier.wosWOS:000356417500011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherK Faisal Spec Hosp Res Centre
dc.relation.ispartofAnnals of Saudi Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCoronary-Artery-Disease
dc.subjectCardiovascular-Disease
dc.subjectRisk-Factors
dc.subjectPopulation
dc.subjectMechanisms
dc.subjectMice
dc.titleAssociation of endothelial nitric oxide synthase Glu298Asp gene polymorphism in psoriasis cases with hypertension
dc.typeArticle

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