Piperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells

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dc.authoridYurdakok-Dikmen, Begum/0000-0002-0385-3602
dc.authoridMeral, Ogunc/0000-0001-8813-4991
dc.contributor.authorKismali, Gorkem
dc.contributor.authorCeylan, Ahmet
dc.contributor.authorMeral, Ogunc
dc.contributor.authorAlpay, Merve
dc.contributor.authorKosova, Funda
dc.contributor.authorCakir, Dilek Ulker
dc.contributor.authorYurdakok-Dikmen, Begum
dc.date.accessioned2025-01-27T20:24:30Z
dc.date.available2025-01-27T20:24:30Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To investigate whether piperlongumine can sensitize prostate cancer cells to tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) and trigger apoptosis in prostate cells. Methods: Human prostate cancer cell lines PC3, LNCaP, and VCaP were cultured with piperlongumine and TRAIL. Then, cell proliferation, migration, caspase activation, apoptotic protein expressions, and death receptor expressions were measured. Results: Piperlongumine inhibited cell proliferation at low doses (<10 mu M) alone and in combination with TRAIL (25 ng/mL), induced apoptosis, and suppressed cyclooxygenase activation. Additionally, piperlongumine induced expression of death receptors which potentiated TRAIL-induced apoptosis in cancer cells but did not affect decoy receptors. Piperlongumine also downregulated tumor cell-survival pathways, inhibited colony formation and migration of cancer cells alone or in combination with TRAIL. The combination of piperlongumine with TRAIL was found to be synergistic. Conclusions: Our findings indicate that piperlongumine can sensitize cancer cells to TRAIL through the upregulation of death receptors and can trigger apoptosis with the downregulation of anti- apoptotic proteins.
dc.description.sponsorshipTurkish Scientific Council (TUBITAK) [115S942]
dc.description.sponsorshipThis work was supported by the Turkish Scientific Council (TUBITAK), Grant#115S942.
dc.identifier.doi10.4103/2221-1691.281465
dc.identifier.endpage223
dc.identifier.issn2221-1691
dc.identifier.issn2588-9222
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85084237600
dc.identifier.scopusqualityQ2
dc.identifier.startpage216
dc.identifier.urihttps://doi.org/10.4103/2221-1691.281465
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22249
dc.identifier.volume10
dc.identifier.wosWOS:000530282000003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofAsian Pacific Journal of Tropical Biomedicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectDeath
dc.subjectRos
dc.subjectMitochondria
dc.subjectActivation
dc.subjectMechanisms
dc.subjectPrevention
dc.subjectMigration
dc.subjectMolecule
dc.subjectInvasion
dc.subjectTherapy
dc.titlePiperlongumine inhibits cell growth and enhances TRAIL-induced apoptosis in prostate cancer cells
dc.typeArticle

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