Investigating the Correlation Between Long-Term Response in Patients with Metastatic HER2+Breast Cancer and the Activity of Regulatory T Cells: A Retrospective Study

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dc.contributor.authorDegirmenci, Mustafa
dc.contributor.authorDiniz, Gulden
dc.contributor.authorKahraman, Dudu Solakoglu
dc.contributor.authorSahbazlar, Mustafa
dc.contributor.authorKoral, Lokman
dc.contributor.authorVarol, Umut
dc.contributor.authorUslu, Ruchan
dc.date.accessioned2025-01-27T20:50:28Z
dc.date.available2025-01-27T20:50:28Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Trastuzumab is commonly utilized in the management of metastatic HER2-positive breast cancer. Our main goal was to examine the clinical outcomes and immune markers of patients who received trastuzumab and chemotherapy treatment. Methods: Between 1995 and 2012, a total of 98 patients diagnosed with metastatic HER2-positive breast cancer were retrospectively analyzed at Ege University Hospital and Tepecik Training and Research Hospital. The clinicopathological characteristics and clinical outcomes of the patients were assessed, and the associations between response rates, survival and the immune profiles of tumor infiltrating lymphocytes were statistically evaluated. Results: The average age of patients at the time of diagnosis was 50.1 +/- 10.3 (ranging from 30 to 79) years. The mean follow-up period for all patients was 97.9 +/- 53.8 months. Among the patients, complete response was observed in 24.5%, partial response in 61.2%, and stable disease in 8.2% of cases. The average progression-free survival was 50.3 +/- 26.9 months (ranging from 1 to 163 months), and the average overall survival was 88.8 +/- 59.4 months (ranging from 12 to 272 months). After analyzing all cases, it was found that patients who were younger (p=0.006), exhibited higher CD3-positivity (p=0.041), presented with higher FOXP3-positivity (p=0.025), showed complete or at least partial response to treatment (p=0.008), and experienced a long-term response to trastuzumab (and chemotherapy) treatment had longer survival (p=0.001). Conclusion: Patients with HER2-positive breast cancer, who initially respond positively to palliative trastuzumab and chemotherapy treatment, can achieve long-term tumor remission lasting for several years.
dc.identifier.doi10.2147/BCTT.S470570
dc.identifier.endpage655
dc.identifier.issn1179-1314
dc.identifier.pmid39355199
dc.identifier.scopus2-s2.0-85205968643
dc.identifier.scopusqualityQ3
dc.identifier.startpage645
dc.identifier.urihttps://doi.org/10.2147/BCTT.S470570
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25500
dc.identifier.volume16
dc.identifier.wosWOS:001325269000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofBreast Cancer-Targets and Therapy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectmetastatic breast cancer
dc.subjecttrastuzumab
dc.subjectforkhead box p3
dc.subjectlong-term response
dc.titleInvestigating the Correlation Between Long-Term Response in Patients with Metastatic HER2+Breast Cancer and the Activity of Regulatory T Cells: A Retrospective Study
dc.typeArticle

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