Synthesis and characterization of poly(N-(2-mercaptoethyl) acrylamide) microgel for biomedical applications

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dc.authoridBütün Şengel, Sultan / 0000-0001-7036-2224
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorBütün Şengel, Sultan
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:39:27Z
dc.date.available2025-01-27T20:39:27Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractN-(2-mercaptoethyl) acrylamide (MEAM) monomer was synthesized by acrylation of cysteamine and was cross-linked with ethylene glycol dimethacrylate (EGDMA) via dispersion polymerization forming poly(N-(2-mercaptoethyl) acrylamide) (p(MEAM)) microgel. Then, the prepared microgels were tested for potential biomedical use, eg, antioxidant capacity and blood compatibility, cytotoxicity, apoptotic, and necrotic cell death; drug delivery properties were determined. Antioxidant studies of p(MEAM) microgels revealed a super antioxidant capability with total phenol content and trolox equivalent antioxidant capacity as 6.05 +/- 1.15 mg/L gallic acid equivalency and 40.96 +/- 2.40 mM trolox/g, respectively. Moreover, the blood compatibility of p(MEAM) microgels on fresh blood was resulted in lower than 1.0% hemolysis ratios for all the studied concentration range, and the blood clotting index was determined as 60.66% at 2.0 mg/mL at microgel concentration. The biocompatibility studies employing WST-1 test on L929 fibroblast cells and DLD-1 colon cancer cells have shown that p(MEAM) microgel was biocompatible up to 200 mu g/mL concentration with the cell viability values of 84.54% and 86.15% on L929 fibroblast and DLD-1 colon cancer cells, respectively. Using Captopril was used as model drug to test p(MEAM) microgel as drug delivery device for in vitro release studies at different pHs. Release profile of Captopril was found linear up to 5 hours with the released amounts of 9.81, 12.24, and 13.78 mg g(-1)microgel at the pH 1.5, 7.4, and 9.0, respectively.
dc.identifier.doi10.1002/pat.4644
dc.identifier.endpage2121
dc.identifier.issn1042-7147
dc.identifier.issn1099-1581
dc.identifier.issue8
dc.identifier.scopus2-s2.0-85068768181
dc.identifier.scopusqualityQ2
dc.identifier.startpage2109
dc.identifier.urihttps://doi.org/10.1002/pat.4644
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23950
dc.identifier.volume30
dc.identifier.wosWOS:000474708800021
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPolymers For Advanced Technologies
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectacrylamidebiocompatibility
dc.subjectacrylation of cysteamine
dc.subjectantioxidant material
dc.subjectdrug delivery
dc.subjectrelease
dc.subjectmicrogel
dc.subjectnanogel
dc.subjectN-(2-mercaptoethyl) hemocompatibility
dc.titleSynthesis and characterization of poly(N-(2-mercaptoethyl) acrylamide) microgel for biomedical applications
dc.typeArticle

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