Acute and subchronic effects of cellulose nanofibers on histological, antioxidant, and acetylcholine responses in the Mediterranean mussel (Mytilus galloprovincialis)

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dc.authorid0000-0003-3319-0616
dc.authorid0000-0001-7861-3999
dc.contributor.authorGurkan, Mert
dc.contributor.authorGurkan, Selin Erturk
dc.contributor.authorGunes, Berkay
dc.contributor.authorSaritunc, Volkan
dc.date.accessioned2026-02-03T12:02:41Z
dc.date.available2026-02-03T12:02:41Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe utilisation of cellulose nanofibrils (CNFs) in industrial applications has seen a marked increase, giving rise to concerns regarding their potential impacts on aquatic ecosystems. The present study evaluated the acute (96 h) and sub-chronic (14 days) effects of CNFs at environmentally relevant concentrations (10, 100, and 1000 mu g/L) on the Mediterranean mussel (Mytilus galloprovincialis), a species of particular importance in marine food webs. A comprehensive analysis of the Gill and mantle tissues was conducted to ascertain any potential histopathological alterations or antioxidant responses. This analysis encompassed the measurement of superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST) activities, along with the assessment of acetylcholinesterase (AChE) activity in the mantle tissue. This approach was undertaken to evaluate the potential for neurotoxic effects. CNF exposure has been demonstrated to induce histological changes, including epithelial deformation and hemocyte infiltration, indicating oxidative damage and activation of cellular defense mechanisms. Oxidative stress parameters demonstrated a concentration-dependent increase in reactive oxygen species (ROS) under both exposure durations. AChE activity also increased, likely reflecting a compensatory response to maintain neural homeostasis. The results demonstrate that CNFs trigger coordinated antioxidant and neuroregulatory responses in M. galloprovincialis, with effects becoming more pronounced at higher concentrations and longer exposures. These findings emphasise the potential for sub-lethal effects on marine bivalves even from biodegradable nanomaterials, underscoring the necessity for comprehensive ecotoxicological assessment of nanoscale cellulose in aquatic environments and highlighting the broader implications for environmental management, regulatory policies, and safe application of nanocellulose-based products.
dc.description.sponsorshipCanakkale Onsekiz Mart University (COMUE) Scientific Research Projects Unit (BAP) [FBA-2024-4885]
dc.description.sponsorshipThis study was supported by the Canakkale Onsekiz Mart University (COMUE) Scientific Research Projects Unit (BAP) under project number FBA-2024-4885.
dc.identifier.doi10.1016/j.marpolbul.2025.118987
dc.identifier.issn0025-326X
dc.identifier.issn1879-3363
dc.identifier.pmid41289857
dc.identifier.scopus2-s2.0-105022815389
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.marpolbul.2025.118987
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34821
dc.identifier.volume223
dc.identifier.wosWOS:001629506900002
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofMarine Pollution Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectNanomaterials
dc.subjectBivalvia
dc.subjectEcotoxicity
dc.subjectOxidative stress
dc.titleAcute and subchronic effects of cellulose nanofibers on histological, antioxidant, and acetylcholine responses in the Mediterranean mussel (Mytilus galloprovincialis)
dc.typeArticle

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