Decellularized Bone Extracellular Matrix-Coated Electrospun PBAT Microfibrous Membranes with Cell Instructive Ability and Improved Bone Tissue Forming Capacity

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dc.authoridARSLAN, Yavuz Emre/0000-0003-3445-1814
dc.authoridERDOGAN, Yasar Kemal/0000-0002-5662-5398
dc.authoridERCAN, BATUR/0000-0003-1657-1142
dc.authoridDerkus, Burak/0000-0001-5558-0995
dc.contributor.authorKarakaya, Ece
dc.contributor.authorErdogan, Yasar Kemal
dc.contributor.authorArslan, Tugba Sezgin
dc.contributor.authorArslan, Yavuz Emre
dc.contributor.authorOdabas, Sedat
dc.contributor.authorErcan, Batur
dc.contributor.authorEmregul, Emel
dc.date.accessioned2025-01-27T20:22:48Z
dc.date.available2025-01-27T20:22:48Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCurrent approaches to develop bone tissue engineering scaffolds have some limitations and shortcomings. They mainly suffer from combining mechanical stability and bioactivity on the same platform. Synthetic polymers are able to produce mechanically stable sturctures with fibrous morphology when they are electrospun, however, they cannot exhibit bioactivity, which is crucial for tissue engineering and regenerative medicine. One current strategy to bring bioactivity in synthetic materials is to combine extracellular matrix (ECM)-sourced materials with biologically inert synthetic materials. ECM-sourced materials without any modifications are mechanically unstable; therefore, reinforcing them with mechanically stable platforms is indispensable. In order to overcome this bifacial problem, we have demonstrated that poly(butylene adipate-co-terephthalate) (PBAT) electrospun microfibrous membranes can be successfully modified with decellularized bone ECM to endow fibers with bioactive hydrogel and mimic natural micro-features of the native bone tissue. The developed structures have been shown to support osteogenesis, confirmed by histochemical staining and gene expression studies. Furthermore, ECM-coated PBAT fibers, when they were aligned, supplied an improved level of osteogenesis. The strategy demonstrated can be adapted to any other tissues, and the emerging microfibrous, mechanically stable, and bioactive materials can find implications in the specific fields of tissue engineering and regenerative medicine.
dc.identifier.doi10.1002/mabi.202200303
dc.identifier.issn1616-5187
dc.identifier.issn1616-5195
dc.identifier.issue12
dc.identifier.pmid36129099
dc.identifier.scopus2-s2.0-85138384403
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mabi.202200303
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22034
dc.identifier.volume22
dc.identifier.wosWOS:000855766800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Bioscience
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbone tissue engineering
dc.subjectdecellularization
dc.subjectelectrospinning
dc.subjectextracellular matrix
dc.subjectmicrofibrous membrane
dc.subjectpoly(butylene adipate-co-terephthalate)
dc.titleDecellularized Bone Extracellular Matrix-Coated Electrospun PBAT Microfibrous Membranes with Cell Instructive Ability and Improved Bone Tissue Forming Capacity
dc.typeArticle

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