GCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT

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dc.contributor.authorYıldırım, Yağmur Deniz
dc.contributor.authorErcan, Esra
dc.contributor.authorGüncü, Güliz Nigar
dc.contributor.authorKarabulut, Erdem
dc.contributor.authorBerker, Ezel
dc.date.accessioned2025-01-27T19:47:43Z
dc.date.available2025-01-27T19:47:43Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and Aim: Diabetes mellitus-related chronic complications can affect multiple organs, including the macrovascular and microvascular systems, as well as the periodontium. Advanced glycation end products (AGE), its receptor (RAGE) and soluble receptor (sRAGE) interaction is critically involved in the pathobiology of both diseases. Monocyte chemoattractant protein-1 (MCP-1) is an essential chemokine responsible for the recruitment of monocytes to inflammatory lesions in the vasculature, an initial step of atherosclerosis. This study aimed to compare the levels of MCP-1 and sRAGE in the gingival crevicular fluid (GCF) of periodontitis patients with type 2 diabetes and those without, hypothesizing that these levels may vary based on diabetic status Materials and Methods: Nine patients with periodontitis and diabetes (DP), 12 periodontitis (P) patients without diabetes, 12 systemically and periodontally healthy subjects (HC) were enrolled in this case-control study. Clinical periodontal parameters and HbA1c values were evaluated. Gingival crevicular fluid samples were analysed for sRAGE and MCP-1 by an enzyme-linked immunosorbent assay. The significance of differences were assessed with Kruskall-Wallis test. Pairwise comparisons were made with Dunn test. Results: sRAGE and MCP-1 levels were significantly higher in periodontitis group than healthy controls (p<0.05). There was no difference between DP and P groups (p>0.05). Positive correlation was detected between sRAGE and MCP-1 levels in disease groups (p=0.000, r=0.976 for DP group; p=0.000, r=0.982 for P group respectively). Conclusion: MCP-1 and sRAGE may have a functional role in the diabetic-periodontal pathogenesis. Further studies must be carried out to understand the contribution of sRAGE and MCP-1 in periodontal inflammation with or without diabetes.
dc.identifier.endpage139
dc.identifier.issn2146-3964
dc.identifier.issn2146-3972
dc.identifier.issue3
dc.identifier.startpage133
dc.identifier.trdizinid1285755
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1285755
dc.identifier.urihttps://hdl.handle.net/20.500.12428/18701
dc.identifier.volume48
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofClinical Dentistry and Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_TRD_20250125
dc.titleGCF LEVELS OF sRAGE AND MCP-1 IN TYPE-2 DIABETIC PATIENTS WITH PERIODONTITIS: A PRELIMINARY REPORT
dc.typeArticle

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