Comparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia

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dc.authoriduzun, metehan/0000-0003-1406-5473
dc.contributor.authorErbas, Mesut
dc.contributor.authorToman, Huseyin
dc.contributor.authorSahin, Hasan
dc.contributor.authorKiraz, Hasan Ali
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorSimsek, Tuncer
dc.contributor.authorYener, Ali Umit
dc.date.accessioned2025-01-27T20:55:44Z
dc.date.available2025-01-27T20:55:44Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPURPOSE: To compare the effects of sugammadex and neostigmine, used to antagonize the effects of rocuronium, on the QT(c) interval. METHODS: This study used 10 adult New Zealand white rabbits of 2.5-3.5 kg randomly divided into two groups: sugammadex group (Group S, n: 5) and neostigmine group (Group N, n: 5). For general anesthesia administering 2 mg/kg iv propofol and 1 mcg/kg iv fentanyl, 0.6 mg/kg iv rocuronium was given. Later to provide reliable airway for all experimental animals V-Gel Rabbit was inserted. The rabbits were manually ventilated by the same anesthetist. After the V-Gel Rabbit was inserted at 2, 5, 10, 20, 25, 27, 30 and 40 minutes measurements were repeated and recorded. At 25 minutes after induction Group N rabbits were given 0.05 mg/kg iv neostigmine + 0.01 mg/kg iv atropine. Group S were administered 2 mg/kg iv sugammadex. RESULTS: Comparing the QT(c) interval in the rabbits in Group S and Group N, in the 25th, 27th and 30th minute after muscle relaxant antagonist was administered the QT(c) interval in the neostigmine group rabbits was significantly increased (p < 0.05). CONCLUSION: While sugammadex, administered to antagonize the effect of rocuronium, did not significantly affect the QTc interval, neostigmine+atropine proloned the QT(c) interval.
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Projects Coordination Unit [TSA-2013-80]
dc.description.sponsorshipCanakkale Onsekiz Mart University, Scientific Research Projects Coordination Unit (TSA-2013-80)
dc.identifier.doi10.1590/S0102-86502014001900007
dc.identifier.endpage811
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.issue12
dc.identifier.pmid25517494
dc.identifier.scopus2-s2.0-84920998458
dc.identifier.scopusqualityQ2
dc.identifier.startpage807
dc.identifier.urihttps://doi.org/10.1590/S0102-86502014001900007
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26150
dc.identifier.volume29
dc.identifier.wosWOS:000346474400007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSugammadex
dc.subjectElectrocardiography
dc.subjectNeostigmine
dc.subjectRabbits
dc.titleComparison of effects of sugammadex and neostigmine on QTc prolongation in rabbits under general anesthesia
dc.typeArticle

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