Diagnostic value of prostate-specific antigen (PSA) and free prostate specific antigen (fPSA) in women with ovulatory and anovulatory polycystic ovary syndrome

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dc.authoridUkinc, KUBILAY/0000-0002-4727-7432
dc.contributor.authorUkinc, Kubilay
dc.contributor.authorErsoz, Halil Onder
dc.contributor.authorErem, Cihangir
dc.contributor.authorHacihasanoglu, Arif Bayram
dc.date.accessioned2025-01-27T20:52:34Z
dc.date.available2025-01-27T20:52:34Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDiagnosis of polycystic ovary syndrome (PCOS) is very difficult in women with ovulatory cycles. We assessed the diagnostic value of prostate-specific antigen (PSA) and free prostate-specific antigen (fPSA) in women with ovulatory or anovulatory PCOS. Study group consisted of 62 women with PCOS and 35 healthy female controls. PCOS group was divided into two subgroups as anovulatory (n = 42; 68%, Group A) and ovulatory group (n = 20; 32%, Group B). A cut-off level of PSA and fPSA was established for the sensitivity, specificity, positive likelihood ratio, area under curve, diagnostic accuracy, and positive and negative predictive values of diagnosis of PCOS. In group A, a PSA level of greater than 10 pg/ml yielded a sensitivity of 73.2%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 88.2% and a negative predictive value of 59.3%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 71.2%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 87.2% and a negative predictive value of 58.4%. In group B, a PSA level of greater than 10 pg/ml yielded a sensitivity of 65%, a specificity of 80%, and a diagnostic accuracy of 73%, with a positive predictive value of 76.5% and a negative predictive value of 69.6%. An fPSA level of greater than 2.1 pg/ml yielded a sensitivity of 65.4%, a specificity of 80.4%, and a diagnostic accuracy of 87%, with a positive predictive value of 75.5% and a negative predictive value of 68.4%. Circulating androgens and hirsutism are independently associated with the degrees of PSA and fPSA in PCOS women. Increased plasma levels of PSA (> 10 pg/ml) and fPSA (> 2.1 pg/ml) could be helpful as a diagnostic tool for women with ovulatory or anovulatory PCOS.
dc.identifier.doi10.1007/s12020-008-9130-6
dc.identifier.endpage129
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue1
dc.identifier.pmid19009369
dc.identifier.scopus2-s2.0-63449101462
dc.identifier.scopusqualityQ2
dc.identifier.startpage123
dc.identifier.urihttps://doi.org/10.1007/s12020-008-9130-6
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25796
dc.identifier.volume35
dc.identifier.wosWOS:000262650400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofEndocrine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHirsutism
dc.subjectProstate-specific antigen (PSA)
dc.subjectFree prostate specific antigen (fPSA)
dc.subjectOvulatory PCOS
dc.subjectAnovulatory PCOS
dc.titleDiagnostic value of prostate-specific antigen (PSA) and free prostate specific antigen (fPSA) in women with ovulatory and anovulatory polycystic ovary syndrome
dc.typeArticle

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