In vitro genotoxic and cytotoxic effects of doxepin and escitalopram on human peripheral lymphocytes

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dc.authoridCAYIR, AKIN/0000-0002-2014-6635
dc.contributor.authorCobanoglu, Hayal
dc.contributor.authorCoskun, Mahmut
dc.contributor.authorCayir, Akin
dc.contributor.authorCoskun, Munevver
dc.date.accessioned2025-01-27T20:14:13Z
dc.date.available2025-01-27T20:14:13Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAntidepressants are drugs used for the treatment of many psychiatric conditions including depression. There are findings suggesting that these drugs might have genotoxic, carcinogenic, and/or mutagenic effects. Therefore, the present in vitro study is intended to investigate potential genotoxic and cytotoxic effects of the antidepressants escitalopram (selective serotonin reuptake inhibitor) and doxepin (Tricyclic antidepressant) on human peripheral lymphocytes cytokinesis-block micronucleus (CBMN), sister chromatid exchange (SCE), and single cell gel electrophoresis (alkaline comet assay) were used for the purpose of the study. In the study, four different concentrations of both drugs (1, 2.5, 5, and 10 mu g/mL) were administered to human peripheral lymphocytes for 24h. The tested concentrations of both drugs were found to exhibit no cytotoxic and mitotic inhibitory effects. SCE increase caused by 5 and 10 mu g/mL of escitalopram was found statistically significant, while no statistically significant increase was observed in DNA damage and micronucleus (MN) formation. Moreover, the increase caused by doxepin in MN formation was not found statistically significant. Besides, 10 mu g/mL of doxepin was demonstrated to significantly increase arbitrary unit and SCE formation. These findings suggest that the investigated concentrations of escitalopram and doxepin were non-cytotoxic but potentially genotoxic at higher concentrations.
dc.description.sponsorshipCanakkale Onsekiz Mart University research fund [FDK-2013-101]
dc.description.sponsorshipThis investigation was supported by Canakkale Onsekiz Mart University research fund (Project no: FDK-2013-101).
dc.identifier.doi10.1080/01480545.2017.1365885
dc.identifier.endpage244
dc.identifier.issn0148-0545
dc.identifier.issn1525-6014
dc.identifier.issue2
dc.identifier.pmid28854817
dc.identifier.scopus2-s2.0-85028746413
dc.identifier.scopusqualityQ1
dc.identifier.startpage238
dc.identifier.urihttps://doi.org/10.1080/01480545.2017.1365885
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21000
dc.identifier.volume41
dc.identifier.wosWOS:000423739400018
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofDrug and Chemical Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectGenotoxicity
dc.subjectcytotoxicity
dc.subjectsister chromatid exchange
dc.subjectmicronucleus
dc.subjectcomet assay
dc.subjectdoxepin and escitalopram
dc.titleIn vitro genotoxic and cytotoxic effects of doxepin and escitalopram on human peripheral lymphocytes
dc.typeArticle

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