Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.contributor.authorKilic, S.
dc.contributor.authorSılan, Fatma
dc.contributor.authorHiz, M. M.
dc.contributor.authorIsik, S.
dc.contributor.authorOgretmen, Z.
dc.contributor.authorOzdemir, O.
dc.date.accessioned2025-01-27T20:14:36Z
dc.date.available2025-01-27T20:14:36Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground and Objective: The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. Patients and Methods: This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in canakkale, Turkey. Peripheral blood samples were collected in EDTA tubes. DNA extraction was performed using the spin column procedure. The VDR polymorphisms Fokl (rs2228570), Bsml (rs1544410), Apal (rs7975232), and Taql (rs731236) were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in 42 atopic dermatitis patients and 96 healthy individuals from a Turkish population. Results: The VDR rs1544410 polymorphism increased the risk of atopic dermatitis in our Turkish population [OR, 12.2; 95%CI, 0.44-336; P=.05]. The Foql, Taql, and Apal polymorphisms were not significantly associated with atopic dermatitis susceptibility. Conclusion: The VDR Fok1, Taql, and Apal gene polymorphisms were not associated with the risk of atopic dermatitis in the Turkish population but the Bsml polymorphism was found to increase risk.
dc.description.sponsorshipProject Foundation of Canakkale Onsekiz Mart University (COMU Research Foundation) [TSA-2013-75]
dc.description.sponsorshipThis study was supported by the sub-item of 2013 Project Foundation of Canakkale Onsekiz Mart University (COMU Research Foundation; No. TSA-2013-75).
dc.identifier.doi10.18176/jiaci.0020
dc.identifier.endpage110
dc.identifier.issn1018-9068
dc.identifier.issn1698-0808
dc.identifier.issue2
dc.identifier.pmid27164626
dc.identifier.scopus2-s2.0-84964430242
dc.identifier.scopusqualityQ2
dc.identifier.startpage106
dc.identifier.urihttps://doi.org/10.18176/jiaci.0020
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21149
dc.identifier.volume26
dc.identifier.wosWOS:000376832700005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEsmon Publicidad S A, Dept Allergy & Clin Immunol, Clin Univ Navarra
dc.relation.ispartofJournal of Investigational Allergology and Clinical Immunology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectFokl
dc.subjectrs2228570
dc.subjectBsml
dc.subjectrs1544410
dc.subjectApal
dc.subjectrs7975232
dc.subjectTaql
dc.subjectrs731236
dc.titleVitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis
dc.typeArticle

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