H-FABP, cardiovascular risk factors, and functional status in asymptomatic spinal cord injury patients

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dc.contributor.authorAkbal, A.
dc.contributor.authorKurtaran, A.
dc.contributor.authorSelcuk, B.
dc.contributor.authorAkyuz, M.
dc.date.accessioned2025-01-27T20:11:47Z
dc.date.available2025-01-27T20:11:47Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis was a cross-sectional study in the setting of a rehabilitation hospital. The aim of the study was to determine the serum levels of heart-type fatty acid-binding protein (H-FABP) in patients with spinal cord injury (SCI). A further goal was to examine whether there is a relationship between H-FABP levels and Functional Ambulation Classification (FAC) scale, Functional Independence Measure (FIM) score, American Spinal Injury Association (ASIA) status, and metabolic syndrome (MetS). The study included 56 SCI patients and 37 age- and sex-matched healthy control subjects who had not been diagnosed with coronary artery disease in the past. Serum H-FABP levels were significantly higher in patients with SCI than in control subjects: paraplegia group, 18.5 +/- 11.4; tetraplegia group, 16.3 +/- 9.1; control group, 6.7 +/- 5.1 ng/ml (p < 0.001). There was no difference between the other cardiac enzymes (troponin I, AST, ALT, CK, CK-MB, and LDH) among the groups. The relationship between the serum H-FABP levels and FAC status was examined. There was a negative correlation between FAC status and H-FABP levels (p < 0.001, r = -aEuro parts per thousand 0.581). Patients with complete SCI were divided into two groups according to the level of the lesion: (lesion levels in C6-T6, n = 25; lesion levels in T7-L2, n = 11). In patients with complete motor injury, H-FABP levels were higher in subjects with injuries above T6 than in those with injuries below T6 (24.21 +/- 10.1 and 14.1 +/- 10.4, respectively; p = 0.011). Serum levels of H-FABP were higher in SCI patients with MetS (n = 10) than in those without MetS (n = 46; 25.8 +/- 11.6 ng/ml vs. 16.42 +/- 10.3 ng/ml, respectively; p = 0.014). Patients were then divided into two groups according to SCI duration: < 12 months (n = 27) and > 12 months (n = 29). H-FABP levels showed statistically significant differences between the two groups (14.8 +/- 11.7 ng/dl and 20.9 +/- 9.9 ng/dl, respectively; p = 0.036). H-FABP is related to MetS and FAC status in asymptomatic SCI patients.
dc.identifier.doi10.1007/s00059-013-3779-1
dc.identifier.endpage635
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue6
dc.identifier.pmid23483223
dc.identifier.scopus2-s2.0-84885669773
dc.identifier.scopusqualityQ3
dc.identifier.startpage629
dc.identifier.urihttps://doi.org/10.1007/s00059-013-3779-1
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20727
dc.identifier.volume38
dc.identifier.wosWOS:000324817500009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.ispartofHerz
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectSpinal cord injury
dc.subjectHeart type fatty acid binding protein
dc.subjectCardiac damage
dc.subjectMetabolic syndrome
dc.subjectFunctional ambulation classification status
dc.titleH-FABP, cardiovascular risk factors, and functional status in asymptomatic spinal cord injury patients
dc.typeArticle

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