Novel Therapeutics for Thromboprophylaxis in Nonvalvular Atrial Fibrillation

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dc.contributor.authorGazi, Emine
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorColkesen, Yucel
dc.date.accessioned2025-01-27T20:29:36Z
dc.date.available2025-01-27T20:29:36Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAtrial fibrillation (AF) is both a health and a social problem. AF is related to the elevated risk of thromboembolic events with stroke being the most important. It adversely affects life expectancy and quality. The risk of ischemic stroke is increased fivefold in patients with AF. Therapeutic options for lowering the risk of stroke in patients with AF consist of vitamin K antagonists and antiplatelet agents, which have relative risk reductions of approximately 60% and 20%, respectively. Alternative therapeutic options available to reduce the risk of stroke in patients with nonvalvular AF are relatively new. In recent years, new oral anticoagulants have been introduced for this indication. Reversible direct thrombin inhibitors and factor Xa inhibitors are new oral anticoagulant agents that have demonstrated efficacy and good safety profiles for preventing stroke and embolic events. The intent of this overview is to review the novel oral anticoagulants recommended for stroke prevention in patients with AF.
dc.identifier.doi10.1002/ddr.21106
dc.identifier.endpage491
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299
dc.identifier.issue7
dc.identifier.scopus2-s2.0-84886424033
dc.identifier.scopusqualityQ2
dc.identifier.startpage485
dc.identifier.urihttps://doi.org/10.1002/ddr.21106
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22994
dc.identifier.volume74
dc.identifier.wosWOS:000325858500011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofDrug Development Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectatrial fibrillation
dc.subjectthromboprophylaxis
dc.subjectdabigatran
dc.subjectrivaroxaban
dc.subjectapixaban
dc.subjectedoxaban
dc.subjectbetrixaban
dc.subjecteribaxaban
dc.titleNovel Therapeutics for Thromboprophylaxis in Nonvalvular Atrial Fibrillation
dc.typeReview Article

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