Impact of elevated serum estradiol/free testosterone ratio on male varicose veins in a prospective study

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dc.contributor.authorOzcan, Sedat
dc.contributor.authorOdabasi, Dolunay
dc.contributor.authorKurt, Tolga
dc.contributor.authorGur, Ali Kemal
dc.contributor.authorKunt, Aysegul
dc.contributor.authorBalaharoglu, Yavuz
dc.contributor.authorKunt, Alper Sami
dc.date.accessioned2025-01-27T21:04:13Z
dc.date.available2025-01-27T21:04:13Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAlthough some studies indicate an association between increased levels of estradiol and varicose veins in women, the role of sex hormones on varicose veins have a question mark in men. We investigated estradiol-2/free testosterone (E2/fT) ratio relationship on varicosity in 100 male patients dividing them into two groups. Group A (n = 46) had varicose veins with endocrinological problems, especially infertility, whereas group B (n = 54) also had varicose veins but no endocrinological problems. Venous blood samples were drawn from both groups in the morning to detect the levels of serum estradiol (E2), androstenedione, dehydroepiandrostenedione sulphate and free testosterone (fT). Patient history, physical examination, colour duplex ultrasound of both limbs and classification of CEAP were performed in both groups. Serum E2/fT ratio was calculated in correspondence with CEAP classification. CEAP classification is the varicosity classification, and it is concerned about the clinical class (C), etiology (E), anatomical distribution (A) and underlying pathophysiology (P). E2/fT ratio was significantly higher in group A (4.18 +/- A 0.54) compared with group B (2.98 +/- A 0.36). Moreover, there is a high correlation between serum E2/fT ratio and CEAP clinical classification in group A (4) compared with group B (2). Serum E2/fT ratio is associated with varicose veins in male patients.
dc.identifier.doi10.1007/s00508-014-0652-z
dc.identifier.endpage769
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue19-20
dc.identifier.pmid25409949
dc.identifier.scopus2-s2.0-84943820782
dc.identifier.scopusqualityQ1
dc.identifier.startpage764
dc.identifier.urihttps://doi.org/10.1007/s00508-014-0652-z
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27584
dc.identifier.volume127
dc.identifier.wosWOS:000362900000003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectVaricose veins
dc.subjectChronic venous insufficiency
dc.subjectCEAP classification
dc.subjectSex hormones
dc.titleImpact of elevated serum estradiol/free testosterone ratio on male varicose veins in a prospective study
dc.title.alternativeBedeutung eines erhöhten Serum Östradiol/freies Testosteron Quotienten für Varizen beim Mann in einer prospektiven Studie
dc.typeArticle

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