Peroxisome Proliferator-activated Receptor Gamma Concentrations in Newly Diagnosed Hypertension Patients and the Metabolic Effects of Olmesartan

Background and Aims. We undertook this study to investigate the effects of olmesartan treatment on PPAR-gamma (PPAR-gamma) concentrations and metabolic syndrome (MetS) components in hypertensive (HT) patients. Methods. The study included 46 newly diagnosed hypertensive patients and 30 healthy controls. All hypertensive patients were given 40 mg of olmesartan, and they were evaluated weekly in the first month and then twice weekly during follow-up visits. At the end of 3 months, MetS components were assessed and serum PPAR-gamma transcription factor concentrations were again measured. Results. MetS was noted in 80.4% of HT patients. Serum PPAR-gamma transcription factor concentration were significantly lower in those with HT compared with the controls (p = 0.005). PPAR-gamma concentrations of controls were 1.14-fold higher than hypertensive patients. HDL levels were significantly increased after treatment (p = 0.004), triglyceride, total cholesterol, fasting blood glucose (FBG), and LDL levels were significantly reduced (p <0.05). There was a tendency toward increased PPAR-gamma concentrations after treatment, but these were not statistically significant (p = 0.154). Conclusions. Olmesartan treatment was found to generate beneficial effects on MetS parameters in HT patients but did not produce any significant increases in serum PPAR-gamma transcription factor concentration. (C) 2014 IMSS. Published by Elsevier Inc.