Use of SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Urinary Tract Infection: Is There a Need for Concern?

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dc.authorid0000-0002-4082-6320
dc.authorid0000-0003-1944-2477
dc.authorid0009-0001-3933-6869
dc.authorid0000-0003-4069-0766
dc.authorid0000-0003-2430-8280
dc.authorid0000-0002-7161-2907
dc.authorid0000-0002-2581-6001
dc.contributor.authorYavuz, Demet
dc.contributor.authorCinpolat, Havva Yasemin
dc.contributor.authorDemir, Ayse Kevser
dc.contributor.authorKadi, Nezaket
dc.contributor.authorKal, Oznur
dc.contributor.authorSahin, Iremcan
dc.contributor.authorAlkan, Sevil
dc.date.accessioned2026-02-03T11:59:53Z
dc.date.available2026-02-03T11:59:53Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: This study aimed to investigate urinary tract infections (UTIs) and associated risk factors in patients with type 2 diabetes mellitus and chronic kidney disease (CKD), with or without treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i). Methods: We retrospectively analyzed diabetic CKD patients with available urine culture results. Patients were divided into two groups: those receiving SGLT2i therapy and those not receiving it. The groups were compared retrospectively with respect to the development of urinary tract infection at 12-month follow-up, using clinical and laboratory results. Results: A total of 151 patients with T2DM were included, with a median age of 70 years (range: 61-76), and 84 (56%) were female. Among them, 91 (60%) patients were treated with SGLT2i. BMI, plasma glucose levels, and the urine protein/creatinine ratio were significantly lower in the SGLT2i group (p = 0.002, p = 0.049, and p < 0.001, respectively), while serum urea and creatinine levels were significantly higher (p = 0.048 and p = 0.028, respectively). A total of 59 patients (39.1%) had positive urine cultures, 32 of whom (35.2%) were using SGLT2i. There was no statistically significant difference in UTI incidence between SGLT2i users and non-users (p = 0.298). Among patients with positive cultures, Escherichia coli was the most common pathogen, identified in 52.5% (n = 31) of cases. Patients with positive urine cultures were older (p = 0.005), and 39 (66%) were female (p = 0.038). According to logistic regression analysis, advanced age and female sex were identified as independent risk factors for UTI (p = 0.037; Odds Ratio = 2.172, 95% CI: 1.048-4.502 and p = 0.033; Odds Ratio = 2.169, 95% CI: 1.065-4.415, respectively). Conclusions: In diabetic patients with CKD, the use of SGLT2i reduces proteinuria without increasing the risk of urinary tract infections. Advanced age and female sex are independent risk factors for UTI.
dc.identifier.doi10.3390/jcm14207302
dc.identifier.issn2077-0383
dc.identifier.issue20
dc.identifier.pmid41156171
dc.identifier.scopus2-s2.0-105020308455
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm14207302
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34448
dc.identifier.volume14
dc.identifier.wosWOS:001603773800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectchronic kidney disease
dc.subjectdiabetes
dc.subjectsodium-glucose cotransporter-2 inhibitors
dc.subjectproteinuria
dc.subjecturinary tract infection
dc.titleUse of SGLT2 Inhibitors in Patients with Chronic Kidney Disease and Urinary Tract Infection: Is There a Need for Concern?
dc.typeArticle

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