Creation of a Drug-Coated Glaucoma Drainage Device Using Polymer Technology

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorKravitz, Daniel J.
dc.contributor.authorQadir, Rabah
dc.contributor.authorBlake, Diane A.
dc.contributor.authorHaque, Salima
dc.contributor.authorJohn, Vijay T.
dc.contributor.authorMargo, Curtis E.
dc.date.accessioned2025-01-27T20:45:38Z
dc.date.available2025-01-27T20:45:38Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description18th Annual Meeting of the American-Glaucoma-Society -- MAR 06-09, 2008 -- Washington, DC
dc.description.abstractObjective: To create and test a slow-release antifibrotic drug-coated glaucoma drainage device using in vitro and in vivo experiments. Methods: A slow-release device incorporating mitomycin C in poly(2-hydroxyethyl methacrylate) disks was developed using redox-polymerization techniques. A standardized preparation of this drug delivery device was attached to the Ahmed glaucoma valve (model FP7; New World Medical, Inc, Rancho Cucamonga, California). Semicircular disks (5 x 6 mm) of P(HEMA)-mitomycin C containing varying concentrations of mitomycin C per gram dry weight of the gel were attached to the lower half of an Ahmed glaucoma valve plate. Water was pumped through the modified Ahmed glaucoma valve at a rate comparable to that of aqueous humor outflow, and mitomycin C release was measured. Modified and unmodified Ahmed glaucoma valves were implanted in a rabbit model, and drug release and fibrosis were assessed after 3 months. Results: The P(HEMA)-mitomycin C device released mitomycin C in vitro over 1 to 2 weeks. Studies in rabbits revealed that mitomycin C was released from the disks during the 3-month implantation. Histologic analysis demonstrated a significant reduction in inflammatory reaction and fibrosis in the resulting blebs. Conclusion: Our slow-release drug-coated glaucoma drainage device decreased fibrosis and inflammation in the resulting bleb in a rabbit model. Clinical Relevance: This device could reduce the failure rate of glaucoma drainage devices.
dc.description.sponsorshipAmer Glaucoma Soc
dc.identifier.doi10.1001/archophthalmol.2009.19
dc.identifier.endpage453
dc.identifier.issn0003-9950
dc.identifier.issn1538-3601
dc.identifier.issue4
dc.identifier.pmid19365022
dc.identifier.scopus2-s2.0-65249188782
dc.identifier.scopusqualityN/A
dc.identifier.startpage448
dc.identifier.urihttps://doi.org/10.1001/archophthalmol.2009.19
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24661
dc.identifier.volume127
dc.identifier.wosWOS:000265103400013
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAmer Medical Assoc
dc.relation.ispartofArchives of Ophthalmology
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMitomycin-C
dc.subjectDifferent Biomaterials
dc.subjectAhmed Glaucoma
dc.subjectSurgery
dc.subjectValve
dc.subjectPolypropylene
dc.subjectOutcomes
dc.subjectImplant
dc.subjectSociety
dc.titleCreation of a Drug-Coated Glaucoma Drainage Device Using Polymer Technology
dc.typeConference Object

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