Tumour necrosis factor alpha, interleukin 10 and interleukin 6 gene polymorphisms of ischemic stroke patients in south Marmara region of Turkey

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dc.contributor.authorOzkan, Adile
dc.contributor.authorSılan, Fatma
dc.contributor.authorUludağ, Ahmet
dc.contributor.authorDegirmenci, Yildiz
dc.contributor.authorKaraman, Handan Isin Ozisik
dc.date.accessioned2025-01-27T20:38:53Z
dc.date.available2025-01-27T20:38:53Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Stroke is an important cause of adult mortality and morbidity; however its pathogenesis is still unknown. Several studies have examined to determine the role of genetic polymorphism of proinflammatory cytokines in the occurence of stroke. The objective of this study was to evaluate the relationship between three polymorphisms; including tumour necrosis alpha (TNF alpha)-238 GA, interleukin(IL-10)-1028 GA (rs1800896), IL-6-(rs1800795) and ischemic stroke in a Turkish population. Methods: Forty two stroke patients and 48 healhty controls were genotyped using PCR analysis for TNF alpha-238 G/A, IL-10-1028 GA and IL-6-rs1800795 AG polymorphisms. Results: The frequency of the CC and CG, GG genotype of IL-6 gene (rs1800795) were statiscially significiantly higher in IS patients than controls (for C/C genotype, P=0.03, OR=4.3; 95% CI: 1.13 to 16.29 and for C/G genotype, P=0.04, OR=3.6; 95% CI: 1.03 to 12.95, for G/G genotype, P=0.02, OR=0.25; 95% CI: 0.07-0.85 respectively). Conclusion: IL-6 CC genotyped was found strongly associated with ischemic stroke than other two polymorpisms TNF-alpha and IL-10 in our population.
dc.identifier.endpage13504
dc.identifier.issn1936-2625
dc.identifier.issue10
dc.identifier.pmid26722564
dc.identifier.scopus2-s2.0-85013220053
dc.identifier.scopusqualityN/A
dc.identifier.startpage13500
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23789
dc.identifier.volume8
dc.identifier.wosWOS:000367814200184
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectStroke
dc.subjectTNF-alpha
dc.subjectIL-6
dc.subjectIL-10
dc.subjectpolymorhisms
dc.titleTumour necrosis factor alpha, interleukin 10 and interleukin 6 gene polymorphisms of ischemic stroke patients in south Marmara region of Turkey
dc.typeArticle

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