Long-term dupilumab therapy in Netherton syndrome with severe atopic manifestations: Case report and review of the literature

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dc.authorid0000-0002-2982-3823en_US
dc.authorscopusid58092782500en_US
dc.authorwosid-en_US
dc.contributor.authorÖzkaya, Esen
dc.contributor.authorGünay, Muhammed Burak
dc.contributor.authorBabuna Kobaner, Goncagül
dc.contributor.authorKeskinkaya, Zeynep
dc.contributor.authorGökalp, Mehmet Onur
dc.date.accessioned2024-01-24T06:23:16Z
dc.date.available2024-01-24T06:23:16Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractWe herein present a unique patient of Netherton syndrome (NS) with ichthyosis linearis circumflexa (ILC) lesions associated with severe atopic manifestations since infancy, showing different responses of atopic and ILC lesions to a 2-year dupilumab therapy. The atopic eczematous lesions and pruritus healed remarkably, dramatically improving the patient's quality of life, whilst the scalp hair showed a clinical and light microscopic improvement. The additional recovery in axillary/pubic/extremity hair growth, sweating and nail growth in the presented case was not previously reported in NS patients treated with dupilumab. However, dupilumab had no therapeutic effect on ILC lesions which were not pruritic and showed a treatment-independent wax and waned course.en_US
dc.identifier.citationÖzkaya, E, Günay, MB, Babuna Kobaner, G, Keskinkaya, Z, & Gökalp, MO. (2023) Long-term dupilumab therapy in Netherton syndrome with severe atopic manifestations: Case report and review of the literature. Australas J Dermatol, 64(2), 272–277. https://doi.org/10.1111/ajd.13986en_US
dc.identifier.doi10.1111/ajd.13986
dc.identifier.endpage277en_US
dc.identifier.issn0004-8380
dc.identifier.issn1440-0960
dc.identifier.issue2en_US
dc.identifier.pmid36745433
dc.identifier.scopus2-s2.0-85147518461
dc.identifier.startpage272en_US
dc.identifier.urihttps://doi.org/10.1111/ajd.13986
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5357
dc.identifier.volume64en_US
dc.identifier.wosWOS:000932454300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKeskinkaya, Zeynep
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofAustralasian Journal of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtopic dermatitisen_US
dc.subjectHypohidrosisen_US
dc.subjectHypotrichosisen_US
dc.subjectIchthyosisen_US
dc.subjectNetherton syndromeen_US
dc.subjectPruritusen_US
dc.subjectTherapy-systemicen_US
dc.titleLong-term dupilumab therapy in Netherton syndrome with severe atopic manifestations: Case report and review of the literature
dc.typeArticle

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