Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima-media thickness and endothelium-dependent vasodilation

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dc.authoridTanoglu, Alpaslan/0000-0002-7477-6640
dc.contributor.authorOzalper, Veysel
dc.contributor.authorKara, Muammer
dc.contributor.authorTanoglu, Alpaslan
dc.contributor.authorCetindagli, Ibrahim
dc.contributor.authorOzturker, Coskun
dc.contributor.authorHancerli, Yusuf
dc.contributor.authorHira, Serdar
dc.date.accessioned2025-01-27T20:20:08Z
dc.date.available2025-01-27T20:20:08Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIt has been suggested that there is an ongoing subclinical inflammation in familial Mediterranean fever (FMF) patients also in attack-free periods as well. Due to this ongoing inflammation, endothelial dysfunction (ED) may develop. Previously, ED has been suggested to increase the risk of the atherosclerosis and cardiovascular disease (CVD). Endocan is recognized as a specific molecule of the endothelium and has been shown to increase in some cases associated with inflammation. However, there is not sufficient data whether those with FMF could develop ED in the early period of life. In this study, we aimed to investigate ED and its relation with endocan in young FMF patients. A total of 57 male patients diagnosed with FMF according to the Tel Hashomer criteria and a total of 33 healthy males with similar characteristics to the patient group were included in this research. Complete blood count, erythrocyte sedimentation rate (ESR), fibrinogen, serum glucose, serum LDL cholesterol (LDL-C) and triglyceride (TG), asymmetric dimethylarginine (ADMA), and endocan levels were tested from fasting blood samples. Moreover, carotid intima-media thickness (CIMT) and flow-mediated dilatation (FMD) were measured. The endocan levels of the FMF patients during an attack-free period were significantly higher than those of the control group (p < 0.001). On the other hand, FMD measurements were significantly lower among FMF patients (p < 0.001). ADMA levels were higher in the patient group; however, this difference was similar (p > 0.05). CIMT values were similar among FMF patients and healthy controls (p > 0.05). These results have suggested that ED may develop in the patients with FMF who have no additional CVD risk, even during young adulthood, and endocan may be a favorable biomarker at demonstration of ED than ADMA among FMF patients.
dc.identifier.doi10.1007/s10067-016-3532-2
dc.identifier.endpage2077
dc.identifier.issn0770-3198
dc.identifier.issn1434-9949
dc.identifier.issue9
dc.identifier.pmid28074304
dc.identifier.scopus2-s2.0-85009206623
dc.identifier.scopusqualityQ1
dc.identifier.startpage2071
dc.identifier.urihttps://doi.org/10.1007/s10067-016-3532-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21577
dc.identifier.volume36
dc.identifier.wosWOS:000407563700017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer London Ltd
dc.relation.ispartofClinical Rheumatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCarotid intima-media thickness
dc.subjectEndocan
dc.subjectEndothelial dysfunction
dc.subjectFamilial Mediterranean fever
dc.subjectFlow-mediated dilatation
dc.titleEvaluation of endothelial dysfunction in patients with familial Mediterranean fever: the relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima-media thickness and endothelium-dependent vasodilation
dc.typeArticle

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