Biochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites

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dc.authoridTuru, Dilay/0000-0002-8485-0488
dc.authoridSimsek, Ozcan/0000-0002-3210-7641
dc.authoridAltuner, Ergin Murat/0000-0001-5351-8071
dc.authoridBENEK, Atakan/0000-0001-6726-5968
dc.authoridBOZYEL, Mustafa Eray/0000-0001-5556-4880
dc.contributor.authorCanli, Kerem
dc.contributor.authorBozyel, Mustafa Eray
dc.contributor.authorTuru, Dilay
dc.contributor.authorBenek, Atakan
dc.contributor.authorSimsek, Ozcan
dc.contributor.authorAltuner, Ergin Murat
dc.date.accessioned2025-01-27T20:29:14Z
dc.date.available2025-01-27T20:29:14Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOriganum onites (Lamiaceae) is an Eastern Mediterranean plant that is widely used in Turkish traditional medicine. This study aimed to investigate the biochemical composition, antimicrobial activity, and antioxidant potential of O. onites. In this study, the biochemical composition of the O. onites ethanol extract (OOEt) was analyzed using GC-MS. The antimicrobial activity was investigated using a disk diffusion test and determining minimum inhibitory concentrations (MIC) against 30 microorganism strains, including 28 bacteria (some multidrug-resistant) and 2 fungi. Additionally, the antioxidant activity was evaluated using the DPPH method. The main component identified was carvacrol. OOEt demonstrated antimicrobial activity against a wide range of tested microorganism strains. OOEt displayed the highest activity against E. faecium (a Gram-positive bacterium) at 100 mu L with a 52 mm inhibition zone. Additionally, P. aeruginosa DSMZ 50071 and P. fluorescens P1, which are Gram-negative bacteria, were the most sensitive strains with a 24 mm inhibition zone in 100 mu L of OOEt. The data obtained from A. baumannii (a multidrug-resistant strain) is particularly striking, as higher activity was observed compared to all positive controls. All tested fungal strains showed more effective results than positive controls. The antioxidant activity of OOEt was found to be stronger than that of the positive control, ascorbic acid. This study determined that O. onites has significant antimicrobial and antioxidant potential.
dc.description.sponsorshipDokuz Eylul University Scientific Research Coordination Unit [2019.KB.FEN.014]
dc.description.sponsorshipThis research was funded by Dokuz Eylul University Scientific Research Coordination Unit, project number 2019.KB.FEN.014
dc.identifier.doi10.3390/microorganisms11081987
dc.identifier.issn2076-2607
dc.identifier.issue8
dc.identifier.pmid37630547
dc.identifier.scopus2-s2.0-85168923263
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/microorganisms11081987
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22878
dc.identifier.volume11
dc.identifier.wosWOS:001056893300001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMicroorganisms
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectOriganum onites
dc.subjectantimicrobial activities
dc.subjectantioxidant activity
dc.titleBiochemical, Antioxidant Properties and Antimicrobial Activity of Steno-Endemic Origanum onites
dc.typeArticle

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