The role of salusins and interleukin 12 family in the rosacea pathogenesis

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dc.authoridKESKINKAYA, ZEYNEP/0000-0002-2982-3823
dc.authoridKAYA, OZGE/0000-0001-8062-1664
dc.authoridKARADELI, UMIT/0000-0002-9854-2988
dc.contributor.authorDemir, Nesrin
dc.contributor.authorKaya, Ozge
dc.contributor.authorKeskinkaya, Zeynep
dc.contributor.authorOguz Kilic, Sevilay
dc.contributor.authorEkinci, Alper
dc.contributor.authorKaradeli, Umit
dc.date.accessioned2025-01-27T21:01:35Z
dc.date.available2025-01-27T21:01:35Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Salusins and recently discovered interleukin (IL)-12 family members (IL-35 and IL-39) have been investigated in various disorders associated with chronic inflammation. The aim of this study was to evaluate the roles of salusin-alpha (alpha), salusin-beta (beta), IL-35, and IL-39 in the pathogenesis of rosacea. Methods: This study is a single-center, prospective case-control study performed in a tertiary healthcare institution. Salusin-alpha, salusin-beta, IL-35, and IL-39 were analyzed by enzyme-linked immunosorbent assay method from venous blood of 50 rosacea patients who did not receive any treatment and 50 age-matched healthy controls, and the test results were compared between the two groups as statistically. Results: Patients in the rosacea group (female:male ratio = 1.9:1; median age: 56 years) had significantly higher mean salusin-alpha, IL-35, and IL-39 levels compared with the control group (female:male ratio = 2.1:1; median age: 41 years). There was no statistically significant difference between the two groups in terms of salusin-beta levels. Conclusion: The increased vascularity and Th1-mediated inflammation might be possible explanations for the elevated salusin-alpha and IL-39 levels in rosacea patients. On the other hand, the higher mean IL-35 level detected in the same group was an unexpected finding due to the immunosuppressive effect of the cytokine. Recently, targeted therapies have become popular in many inflammatory diseases. In this context, salusins, IL-35, and IL-39 seem to be possible molecules that could be modified for therapeutic reasons in the future in the treatment of rosacea.
dc.identifier.doi10.4103/tjd.tjd_36_23
dc.identifier.endpage92
dc.identifier.issn1307-7635
dc.identifier.issn1308-5255
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85176401186
dc.identifier.scopusqualityQ4
dc.identifier.startpage88
dc.identifier.urihttps://doi.org/10.4103/tjd.tjd_36_23
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27111
dc.identifier.volume17
dc.identifier.wosWOS:001085135400002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofTurk Dermatoloji Dergisi-Turkish Journal of Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectInterleukin 12
dc.subjectinterleukin 35
dc.subjectinterleukin 39
dc.subjectrosacea
dc.subjectsalusin-alpha
dc.subjectsalusin-beta
dc.titleThe role of salusins and interleukin 12 family in the rosacea pathogenesis
dc.typeArticle

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