Electrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form

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dc.authoridKILINC, Emrah/0000-0002-4583-8371
dc.authoridYilmaz, Selehattin/0000-0003-4607-3523
dc.authoridSaglikoglu, Gulsen/0000-0002-3407-9787
dc.contributor.authorYagmur, S.
dc.contributor.authorYilmaz, S.
dc.contributor.authorSadikoglu, M.
dc.contributor.authorSaglikoglu, G.
dc.contributor.authorYildiz, M.
dc.contributor.authorYengin, C.
dc.contributor.authorKilinc, E.
dc.date.accessioned2025-01-27T20:24:55Z
dc.date.available2025-01-27T20:24:55Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe electrochemical oxidation of phenazopyridine hydrochloride (PAP) was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques at ultra trace graphite electrode (UTGE). PAP exhibited a diffusion controlled process which is pH dependence. The dependence of the current and potential on pH, the concentration and nature of buffer, and scan rate was investigated to optimize the experimental conditions for the determination of PAP. It was found that the optimum buffer for the determination of PAP is 0.1 NaOH solutions with the pH 12.97. In the concentration range from 6.0x10(-8) to 1.0x10(-6) M, the current measured by DPV present a good linear property as a function of the concentration of PAP. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 8.1x10(-10) and 2.7x10(-9) M, respectively. PAP was determined in human urine and tablet dosage form. Precision and accuracy of the developed technique were checked by recovery studies in spiked urine and tablet dosage form. In addition, for the comparison, high performance liquid chromatography (HPLC) technique was applied for the determination of PAP in the same samples.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK) [TBAG-2173, 102T062]; Ege University Department of Scientific Research Projects (BAP) [05/ECZ/007]
dc.description.sponsorshipThe authors gratefully acknowledge to the Scientific and Technical Research Council of Turkey (TUBITAK, Grant No: TBAG-2173; 102T062). The authors would also like to thank Faco Inc., (Istanbul, Turkey) for supplying pure PAP and its commercial tablet forms for proposed voltammety and comparison HPLC technique. Emrah KILINC acknowledges financial support from Ege University Department of Scientific Research Projects (BAP, Project number: 05/ECZ/007).
dc.identifier.endpage6828
dc.identifier.issn1452-3981
dc.identifier.issue5
dc.identifier.scopus2-s2.0-84878689760
dc.identifier.scopusqualityQ3
dc.identifier.startpage6818
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22383
dc.identifier.volume8
dc.identifier.wosWOS:000319861000071
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEsg
dc.relation.ispartofInternational Journal of Electrochemical Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPhenazopyridine hydrochloride
dc.subjectelectrooxidation
dc.subjectdifferential pulse voltammetry
dc.subjectcyclic voltammetry
dc.subjectultra trace graphite electrode
dc.titleElectrooxidation of Phenazopyridine Hydrochloride and its Voltammetric and HPLC Determination in Human Urine and Tablet Dosage Form
dc.typeArticle

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