Association of SARS-CoV-2 cycle threshold (Ct) values with clinical course and serum biomarkers in COVID-19 patients

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dc.authoridAkalin, Halis/0000-0001-7530-1279
dc.authoridOnal, Ugur/0000-0001-6194-3254
dc.authoridSaglik, Imran/0000-0003-0864-4989
dc.authoridYilmaz, Emel/0000-0002-3894-1231
dc.authoridCoskun, Funda/0000-0003-3604-8826
dc.authoridAGCA, HARUN/0000-0002-2651-2034
dc.contributor.authorSaglik, Imran
dc.contributor.authorEner, Beyza
dc.contributor.authorAkalin, Halis
dc.contributor.authorOzdemir, Busra
dc.contributor.authorOcakoglu, Gokhan
dc.contributor.authorYalcin, Baris
dc.contributor.authorOnal, Ugur
dc.date.accessioned2025-01-27T20:22:57Z
dc.date.available2025-01-27T20:22:57Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Our knowledge has gaps regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication levels and its association to severity of Coronavirus disease 2019 (COVID-19). The aim of this study was to investigate the association of SARS-CoV-2 viral load with disease severity and serum biomarkers in COVID-19 patients. Methodology: Viral load was determined via cycle threshold (Ct) values of SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in 214 adult patients. Ct values were compared with clinical severity, biochemical and hematological biomarkers. Results: Clinical course of the disease was mild (49.1%), moderate (40.2%), and severe (10.7%). Median Ct value was 28.2 (IQR: 22.2-33.8) during the first week of the disease. Ct values were lower within five days after symptom onset [lowest Ct value on the third day (median: 24, IQR: 20.6-32.3)], but they increased significantly during the second and third weeks. No association was detected between admission Ct values and disease severity. Gender, age, co-morbidity, and mortality did not differ significantly in patients with low (<= 25) and high (> 25) Ct values. White blood cell, neutrophil, platelet, and especially lymphocyte counts, were significantly lower in patients with low Ct values. Conclusions: No definitive/clear correlation between SARS-CoV-2 viral load and severity and mortality was found in the studied COVID-19 patients. However, neutrophil, platelet, and especially lymphocyte count were significantly lower in patients with a high viral load.
dc.identifier.doi10.3855/jidc.15818
dc.identifier.endpage452
dc.identifier.issn1972-2680
dc.identifier.issue3
dc.identifier.pmid35404849
dc.identifier.scopus2-s2.0-85127974120
dc.identifier.scopusqualityQ2
dc.identifier.startpage445
dc.identifier.urihttps://doi.org/10.3855/jidc.15818
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22079
dc.identifier.volume16
dc.identifier.wosWOS:000786595400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJ Infection Developing Countries
dc.relation.ispartofJournal of Infection in Developing Countries
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCOVID-19
dc.subjectSARS-CoV-2
dc.subjectCt value
dc.subjectseverity
dc.subjectlymphocyte
dc.titleAssociation of SARS-CoV-2 cycle threshold (Ct) values with clinical course and serum biomarkers in COVID-19 patients
dc.typeArticle

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